| Fact Table | |
|---|---|
| Formula | C10H14N2 (nicotine) |
| License | FDA approved (OTC smoking cessation aid); EMA approved |
| Bioavailability | ~50–80% (buccal absorption; reduced if swallowed) |
| Legal status | Over-the-counter (OTC) |
| Chemical Name | (S)-3-(1-methylpyrrolidin-2-yl)pyridine |
| Elimination half-life | ~1–2 hours |
| Dosage (Strength) | 2 mg nicotine polacrilex gum; chew-and-park technique every 1–2 hours as needed |
| Pregnancy | Category D – Use only if potential benefit justifies fetal risk |
| Brands | Nicorette, Nicoderm CQ Gum, generics available |
| Protein binding | <5% |
| PubChem CID | 89594 |
| MedlinePlus | a684027 |
| ChEBI | 18723 |
| ATC code | N07BA01 |
| DrugBank | DB00184 |
| KEGG | D00005 |
| Routes of administration | Buccal (chewing gum) |
Nicorette nicotine gum is a product that helps reduce cravings and withdrawal symptoms in people who quit smoking cigarettes. It releases small amounts of nicotine that the body absorbs through the mouth, supporting the transition away from cigarettes. The 2 mg strength is meant for people who usually smoke their first cigarette more than 30 minutes after waking up. The gum provides a controlled dose of nicotine without the harmful chemicals found in cigarette smoke.
Nicorette Gum 2 mg should be used by adults who smoke fewer than 25 cigarettes per day. The standard method involves chewing one piece of gum every 1 to 2 hours during the first six weeks, with a minimum of 9 pieces per day recommended. Users should not exceed 24 pieces in a single day.
The technique differs from regular chewing gum. A person should chew the gum slowly until they notice a peppery or tingling sensation, then park it between their cheek and gum to allow nicotine absorption. After the tingling fades, they can resume chewing until the sensation returns, repeating this park-and-chew process for about 30 minutes.
Week-by-week reduction schedule:
Avoid eating or drinking anything except water for 15 minutes before and during gum use, as this may reduce nicotine absorption. People who smoke their first cigarette within 30 minutes of waking may need the 4 mg strength instead. Those under 18 years should consult a doctor before starting nicotine gum therapy.
The active ingredient in Nicorette is nicotine polacrilex.
Before using this medication, you may want to consult a healthcare provider about the following:
If you are pregnant or breastfeeding, use Nicorette only if your healthcare provider says it is appropriate. Quitting smoking without nicotine is best, but nicotine replacement is generally considered safer than smoking, even though risks to the baby are not fully known.
Nicorette may not be right for everyone, especially if you have heart disease, a recent heart attack, irregular heartbeat, uncontrolled high blood pressure, diabetes, stomach ulcers, or a history of seizures.
Talk to a doctor or pharmacist before using Nicorette if you take medications for depression or asthma, or if you are using another stop-smoking medication, since dose changes may be needed.
Keep Nicorette out of reach of children and pets, as even small amounts of nicotine can be dangerous. Wrap used gum in paper and throw it away safely, and contact Poison Control immediately if an overdose is suspected.
Avoid taking or using this medication if any of the following apply:
Common side effects of Nicorette include:
These side effects are usually mild and related to the nicotine content or how the gum is chewed.
More serious side effects can include irregular heartbeat, chest pain, or symptoms of nicotine overdose such as weakness, confusion, or fainting.
Severe allergic reactions, such as swelling of the face or throat, trouble breathing, or a severe rash, have also been reported.
Seek medical attention if you develop chest pain, seizures, severe nausea or vomiting, or signs of an allergic reaction while using Nicorette.
What is Nicorette Gum 2 mg used for?
Nicorette Gum 2 mg is an over-the-counter nicotine replacement product used to help people stop smoking by reducing cravings and withdrawal symptoms associated with quitting.
How does Nicorette Gum work?
Nicorette Gum provides a controlled amount of nicotine that is absorbed through the lining of the mouth, helping relieve urges to smoke without exposure to tobacco smoke.
Who should use the 2 mg strength of Nicorette Gum?
The 2 mg strength is intended for people who smoke their first cigarette more than 30 minutes after waking up or who smoke fewer cigarettes per day.
How should Nicorette Gum be used correctly?
Nicorette Gum should be chewed slowly until a tingling sensation is felt, then parked between the cheek and gum, repeating this process for about 30 minutes.
How often can Nicorette Gum be used?
The gum is typically used every one to two hours at first, with gradual reduction over time as cravings decrease.
What are the most common side effects of Nicorette Gum?
Common side effects include mouth or throat irritation, jaw discomfort, hiccups, nausea, and heartburn, especially if chewed too quickly.
Can food or drinks affect Nicorette Gum?
Acidic foods and beverages such as coffee, soda, or juice can reduce nicotine absorption and should be avoided for at least 15 minutes before and during use.
Is Nicorette Gum addictive?
Nicorette Gum contains nicotine, which can be habit-forming, but it is generally considered safer than smoking and is intended for temporary use during smoking cessation.
Who should use caution when using Nicorette Gum?
People with heart disease, irregular heart rhythms, jaw problems, or dental issues should use caution and read product warnings carefully.
What happens if Nicorette Gum is stopped too soon?
Stopping Nicorette Gum too early may lead to a return of nicotine cravings or withdrawal symptoms, which can increase the risk of smoking relapse.
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (e.g., different shape or color), as trademark laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.