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Only Available By Prescription
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
| Fact Table | |
|---|---|
| Formula | C257H383N65O77S6 |
| License | FDA approved |
| Bioavailability | ~70% (subcutaneous injection) |
| Legal status | Prescription and OTC (in some U.S. states) |
| Chemical Name | Insulin, recombinant human |
| Elimination half-life | ~4–6 minutes (short action: ~6–10 hours) |
| Dosage (Strength) | 100 units/mL (U-100) |
| Pregnancy | Category B – Generally safe; consult doctor |
| Brands | Novolin R, Humulin R |
| Protein binding | Negligible |
| PubChem CID | 16129678 |
| MedlinePlus | a682404 |
| ChEBI | 5931 |
| ATC code | A10AB01 |
| DrugBank | DB00030 |
| KEGG | D04444 |
| Routes of administration | Subcutaneous injection, intravenous (hospital use), intramuscular (rare) |
How does Novolin R affect A1c?
By controlling mealtime blood sugar spikes, Novolin R helps lower your A1c, which reflects average blood glucose over 3 months.
What if I accidentally overdose on Novolin R?
Seek emergency medical attention. An overdose can lead to severe hypoglycemia, requiring oral glucose, glucagon, or IV treatment.
Can I adjust my Novolin R dose myself?
No. Any dose changes should be made under a doctor’s guidance. Improper adjustments can cause dangerous lows or highs in blood sugar.
Can Novolin R cause weight gain?
Yes. Like other insulins, it may lead to weight gain due to improved glucose metabolism. Balanced diet and exercise can help.
How often do I take Novolin R?
Usually 2–3 times per day, before meals, depending on your needs and whether you're using basal insulin alongside it.
Can I use Novolin R in an insulin pump?
No. Novolin R is not approved for use in pumps. Rapid-acting analogs (like Novolog) are preferred for pump therapy.
Can I use Novolin R if I have kidney or liver disease?
Yes, but you may need dose adjustments, as insulin sensitivity changes with kidney or liver impairment. Regular monitoring is essential.
How do I avoid lipodystrophy with Novolin R?
Rotate injection sites regularly. Use areas like the abdomen, thigh, or upper arm, and don’t inject into the same spot repeatedly.
How long is Novolin R good once opened?
Once opened and stored at room temperature, it is good for 42 days. After that, it should be discarded.
Does Novolin R interact with other medications?
Yes. Medications like beta-blockers, steroids, diuretics, and alcohol can affect insulin needs. Always review medications with your doctor.
