Novolin R (Insulin)

Novolin R is a short-acting human insulin used to improve glycemic control in patients with type 1 and type 2 diabetes mellitus. It contains recombinant human insulin identical to endogenous insulin and is designed to manage blood glucose levels during meals. Novolin R typically begins working within 30 minutes of administration, peaks between 2.5 to 5 hours, and has a duration of action of up to 8 hours. It is often part of a basal-bolus insulin regimen, paired with intermediate- or long-acting insulins, and may also be used intravenously in clinical settings for rapid blood glucose correction.

Directions

Novolin R is administered subcutaneously 30 minutes before meals in the abdomen, upper arm, thigh, or buttocks. The dosage must be tailored to the individual based on regular blood glucose monitoring, dietary intake, and physical activity. Injection sites should be rotated within the same region to minimize the risk of lipodystrophy. Novolin R may also be given intravenously under medical supervision, typically in emergency or inpatient care. It should not be mixed with other insulins unless instructed by a healthcare provider.

Ingredients

Each mL of Novolin R contains 100 units of human insulin. Inactive ingredients include glycerol, metacresol, zinc, and water for injection. Hydrochloric acid and sodium hydroxide may be used to adjust pH, which is approximately 7.4. The solution is sterile, clear, and colorless.

Contraindications

Novolin R is contraindicated in patients with hypersensitivity to human insulin or any component of the formulation. It must not be used during episodes of hypoglycemia. Intravenous use should only occur in a clinical setting under proper medical supervision.

Cautions

Careful blood glucose monitoring is essential when initiating or adjusting Novolin R therapy. Insulin requirements may be affected by stress, illness, renal or hepatic impairment, or changes in physical activity or diet. Concomitant use of certain medications—such as beta-blockers, diuretics, or corticosteroids—can influence insulin efficacy or mask signs of hypoglycemia. Alcohol may potentiate insulin’s blood sugar-lowering effect, increasing the risk of hypoglycemia. Patients should be trained to recognize early symptoms of low blood sugar and be equipped with fast-acting carbohydrates or glucagon for emergency use.

Side Effects

Possible side effects of Novolin R include:

• Hypoglycemia

• Injection site reactions (e.g., swelling, redness, pain)

• Lipodystrophy (fat thickening or loss at injection sites)

• Allergic reactions (local or systemic)

• Weight gain

• Peripheral edema