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Only Available By Prescription
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Novolin R is a short-acting human insulin used to improve glycemic control in patients with type 1 and type 2 diabetes mellitus. It contains recombinant human insulin identical to endogenous insulin and is designed to manage blood glucose levels during meals. Novolin R typically begins working within 30 minutes of administration, peaks between 2.5 to 5 hours, and has a duration of action of up to 8 hours. It is often part of a basal-bolus insulin regimen, paired with intermediate- or long-acting insulins, and may also be used intravenously in clinical settings for rapid blood glucose correction.
| Fact Table | |
|---|---|
| Formula | C257H383N65O77S6 |
| License | FDA approved |
| Bioavailability | ~70% (subcutaneous injection) |
| Legal status | Prescription and OTC (in some U.S. states) |
| Chemical Name | Insulin, recombinant human |
| Elimination half-life | ~4–6 minutes (short action: ~6–10 hours) |
| Dosage (Strength) | 100 units/mL (U-100) |
| Pregnancy | Category B – Generally safe; consult doctor |
| Brands | Novolin R, Humulin R |
| Protein binding | Negligible |
| PubChem CID | 16129678 |
| MedlinePlus | a682404 |
| ChEBI | 5931 |
| ATC code | A10AB01 |
| DrugBank | DB00030 |
| KEGG | D04444 |
| Routes of administration | Subcutaneous injection, intravenous (hospital use), intramuscular (rare) |
Novolin R is administered subcutaneously 30 minutes before meals in the abdomen, upper arm, thigh, or buttocks. The dosage must be tailored to the individual based on regular blood glucose monitoring, dietary intake, and physical activity. Injection sites should be rotated within the same region to minimize the risk of lipodystrophy. Novolin R may also be given intravenously under medical supervision, typically in emergency or inpatient care. It should not be mixed with other insulins unless instructed by a healthcare provider.
Each mL of Novolin R contains 100 units of human insulin. Inactive ingredients include glycerol, metacresol, zinc, and water for injection. Hydrochloric acid and sodium hydroxide may be used to adjust pH, which is approximately 7.4. The solution is sterile, clear, and colorless.
Novolin R is contraindicated in patients with hypersensitivity to human insulin or any component of the formulation. It must not be used during episodes of hypoglycemia. Intravenous use should only occur in a clinical setting under proper medical supervision.
Careful blood glucose monitoring is essential when initiating or adjusting Novolin R therapy. Insulin requirements may be affected by stress, illness, renal or hepatic impairment, or changes in physical activity or diet. Concomitant use of certain medications—such as beta-blockers, diuretics, or corticosteroids—can influence insulin efficacy or mask signs of hypoglycemia. Alcohol may potentiate insulin’s blood sugar-lowering effect, increasing the risk of hypoglycemia. Patients should be trained to recognize early symptoms of low blood sugar and be equipped with fast-acting carbohydrates or glucagon for emergency use.
Possible side effects of Novolin R include:
How does Novolin R affect A1c?
By controlling mealtime blood sugar spikes, Novolin R helps lower your A1c, which reflects average blood glucose over 3 months.
What if I accidentally overdose on Novolin R?
Seek emergency medical attention. An overdose can lead to severe hypoglycemia, requiring oral glucose, glucagon, or IV treatment.
Can I adjust my Novolin R dose myself?
No. Any dose changes should be made under a doctor’s guidance. Improper adjustments can cause dangerous lows or highs in blood sugar.
Can Novolin R cause weight gain?
Yes. Like other insulins, it may lead to weight gain due to improved glucose metabolism. Balanced diet and exercise can help.
How often do I take Novolin R?
Usually 2–3 times per day, before meals, depending on your needs and whether you're using basal insulin alongside it.
Can I use Novolin R in an insulin pump?
No. Novolin R is not approved for use in pumps. Rapid-acting analogs (like Novolog) are preferred for pump therapy.
Can I use Novolin R if I have kidney or liver disease?
Yes, but you may need dose adjustments, as insulin sensitivity changes with kidney or liver impairment. Regular monitoring is essential.
How do I avoid lipodystrophy with Novolin R?
Rotate injection sites regularly. Use areas like the abdomen, thigh, or upper arm, and don’t inject into the same spot repeatedly.
How long is Novolin R good once opened?
Once opened and stored at room temperature, it is good for 42 days. After that, it should be discarded.
Does Novolin R interact with other medications?
Yes. Medications like beta-blockers, steroids, diuretics, and alcohol can affect insulin needs. Always review medications with your doctor.
