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Fact Table
| Fact Table | |
|---|---|
| Formula | C_27H_36N_2O_5 |
| License | FDA approved April 2015 |
| Bioavailability | Approximately 40% (with food) |
| Legal status | Prescription Drugs |
| Chemical Name | Ivabradine |
| Elimination half-life | 2 hours (range 1-3 hours) |
| Dosage (Strength) | 5 mg and 7.5 mg tablets |
| Pregnancy | Consult Doctor - Category C (Risk not ruled out) |
| Brands | Corlanor |
| Protein binding | 70% |
| PubChem CID | 132999 |
| MedlinePlus | a615034 |
| ChEBI | 85980 |
| ATC code | C01EB17 |
| DrugBank | DB09300 |
| KEGG | D02556 |
| Routes of administration | Oral |
Corlanor (Ivabradine) is a medicine used to treat chronic heart failure in adults to reduce their risk of hospitalization for worsening heart failure. It affects your heart’s electrical activity and slows the heart rate. It is also used in children at least six months old who have stable heart failure caused by an enlarged heart.
Before you buy Corlanor, you must talk to your healthcare provider about its potential side effects and affordability.
Directions
Corlanor is a tablet you take two times a day with meals, such as in the morning with breakfast and with your evening meal. Always follow your doctor’s instructions on exactly how much to take and when.
Ingredients
The active ingredient in Corlanor is Ivabradine. The inactive ingredients in the tablet form include colloidal silicon dioxide, glycerol, hypromellose, lactose monohydrate, magnesium stearate, maize starch, maltodextrin, polyethylene glycol 6000, red iron oxide, titanium dioxide, and yellow iron oxide.
Cautions
You should not use Corlanor if you have severe liver disease, shallow blood pressure, a slow resting heart rate, a serious heart condition such as “sick sinus syndrome” or 3rd-degree “AV block” (unless you have a pacemaker), or if you depend on a pacemaker to control your heart rate. Ivabradine may harm an unborn baby, so use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.
Interactions
There are 382 drugs known to interact with Corlanor (Ivabradine), along with four disease interactions and one alcohol/food interaction. Many medications can interact, and some drugs should not be used together. Avoid grapefruit or grapefruit juice as it may interact with ivabradine and lead to unwanted side effects.
Side Effects
Common side effects of Corlanor include slow or irregular heartbeats, high blood pressure, and your eyes may be more sensitive to light. Serious side effects include chest pressure, racing or pounding heartbeats, very slow heartbeats, weakness, tiredness, severe dizziness, or shortness of breath worse than usual. If you experience any of these side effects, seek medical attention immediately.
Frequently Asked Questions about Corlanor (Ivabradine)
What is Corlanor (Ivabradine)?
Corlanor is a medication indicated for the treatment of stable symptomatic heart failure due to dilated cardiomyopathy (DCM) in pediatric patients aged six months and older who are in sinus rhythm with an elevated heart rate.
What are the contraindications of Corlanor?
Corlanor is contraindicated in patients with acute decompensated heart failure, clinically significant hypotension, sick sinus syndrome, sinoatrial block, 3rd-degree atrioventricular block (unless a functioning demand pacemaker is present), clinically significant bradycardia, severe hepatic impairment, pacemaker dependence (heart rate maintained exclusively by the pacemaker), and concomitant use of strong cytochrome P450 3A4 (CYP3A4) inhibitors.
What are the potential side effects of Corlanor?
The most common side effects of Corlanor include increased blood pressure and temporary brightness in part of your field of vision.
Can Corlanor be used during pregnancy?
Corlanor may cause fetal toxicity when administered to a pregnant woman. Females of reproductive potential are advised to use effective contraception when taking Corlanor.
Does Corlanor increase the risk of atrial fibrillation?
Yes, Corlanor increases the risk of atrial fibrillation. Regular monitoring of cardiac rhythm is recommended.
What should I do if I experience bradycardia while taking Corlanor?
Bradycardia, sinus arrest, and heart block have occurred with Corlanor. If you experience symptoms of a slow heart rate, such as dizziness, fatigue, or lack of energy, you should inform your doctor.
Can Corlanor be taken with other medications?
Corlanor may affect how other medicines work and other medicines may affect how Corlanor works. This could cause serious side effects. It’s important to tell your doctor about all the medicines you take.
What should I do if I become pregnant while taking Corlanor?
If you become pregnant during treatment with Corlanor, you should inform your doctor right away.
Is there any patient support available for Corlanor?
Yes, eligible commercially insured patients may pay as little as $20 per month with the Corlanor Co-Pay Card.
What should I do if I am uninsured and need help paying for Corlanor?
If you are uninsured and need help paying for Corlanor, visit the Amgen Safety Net Foundation website to see if you meet the eligibility criteria.
