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Fact Table
| Fact Table | |
|---|---|
| Formula | C62H111N11O12 |
| License | FDA approved (2002) |
| Bioavailability | Minimal systemic absorption (ophthalmic use) |
| Legal status | Prescription only (Rx) |
| Chemical Name | Cyclic undecapeptide produced by *Tolypocladium inflatum* |
| Elimination half-life | ~6–27 hours (systemic; not clinically relevant for ophthalmic use) |
| Dosage (Strength) | 0.05% ophthalmic emulsion; 1 drop in each eye twice daily (˜12 hours apart) |
| Pregnancy | Category C – Use only if potential benefit justifies risk |
| Brands | Restasis |
| Protein binding | ~90% (systemic data) |
| PubChem CID | 5284373 |
| MedlinePlus | a601207 |
| ChEBI | 4031 |
| ATC code | S01XA18 |
| DrugBank | DB00091 |
| KEGG | D00184 |
| Routes of administration | Ophthalmic (eye drops/emulsion) |
Restasis (cyclosporine) is an eye drop used to treat chronic dry eye. It works as a calcineurin inhibitor immunosuppressant that reduces inflammation on the eye’s surface. As a result, Restasis can help the eyes make more natural tears. It is applied directly to the eyes as a liquid emulsion to relieve dry eye symptoms over time.
Directions
The typical dosage of Restasis is one drop instilled in each eye twice daily, with doses spaced around 12 hours apart. The single-use vials contain enough medication for both eyes and should be discarded after using. The multidose bottle can be used for multiple applications. Restasis may be used with artificial tears, but it’s best to wait at least 15 minutes between using different eye products.
Ingredients
The active ingredient in Restasis eye drops is cyclosporine.
Cautions
- Before using this medication, you may want to consult a healthcare provider about the following:
- Any existing health conditions
- Any allergies
- A list of all medications currently being taken
- Do not let the tip of the vial touch your eye, fingers, or any surface, as this can cause eye injury or contaminate the medication.
- Restasis should not be used while wearing contact lenses, since dry eye disease can make contacts unsafe or uncomfortable.
- If you wear contact lenses, remove them before using Restasis and wait at least 15 minutes after applying the drops before putting them back in.
Contraindications
Avoid taking or using this medication if any of the following apply:
- Known hypersensitivity to cyclosporine
- Suspected allergic reaction to any ingredient in the medication
Side Effects
Common side effects of Restasis include:
- Eye burning or stinging after application
- Eye redness
- Watery eyes
- Eye pain or irritation
- A feeling of something in the eye
If any of these side effects occur, they usually develop in the treated eye shortly after using the drops. Burning or stinging is the most common adverse reaction and often goes away as your eyes adjust to treatment. Mild redness, watering, or irritation can also happen.
More serious side effects are uncommon but may include eye injury or infection if the dropper tip touches the eye or gets contaminated. Contact a healthcare provider if you develop increasing eye pain, persistent redness, vision changes, discharge, or signs of infection such as swelling or sensitivity to light.
Frequently Asked Questions about Restasis
What is Restasis used for?
Restasis is a prescription eye medication used to increase tear production in people with chronic dry eye disease when reduced tear production is thought to be caused by inflammation.
How does Restasis work?
Restasis contains cyclosporine, an immunomodulator that reduces inflammation in the tear-producing glands. By decreasing inflammation, it allows the eyes to produce more natural tears over time.
How is Restasis typically used?
Restasis is usually applied as one drop in each eye twice daily, about 12 hours apart. It is intended for long-term use rather than immediate symptom relief.
How long does it take for Restasis to work?
Some people notice improvement after several weeks, but it may take three to six months of consistent use to experience full benefits in tear production and symptom relief.
What are the most common side effects of Restasis?
The most common side effect is a temporary burning or stinging sensation in the eyes after application. Redness, watery eyes, eye pain, or blurred vision may also occur briefly.
Can Restasis be used with artificial tears?
Yes, artificial tears may be used alongside Restasis, but they should be administered at least 15 minutes apart to avoid diluting the medication.
Is Restasis safe for long-term use?
Restasis is commonly prescribed for long-term management of chronic dry eye and is generally considered safe when used as directed under medical supervision.
Can contact lenses be worn while using Restasis?
Contact lenses should be removed before applying Restasis. Lenses can usually be reinserted after about 15 minutes, unless otherwise directed.
Does Restasis provide immediate relief from dry eye symptoms?
Restasis does not provide instant lubrication like artificial tears. Its benefit comes from improving the eye’s natural ability to produce tears over time.
Is Restasis safe during pregnancy or breastfeeding?
Very little of the medication is absorbed into the bloodstream, but use during pregnancy or breastfeeding should be based on careful consideration of potential benefits and risks.
Thankful for CanPharm
Everything works very well and very pleased. Only recommendation is to give yourself a full month to renew, in case Customs holds things up in the US. Thanks, CanPharm!!
