Rhopressa (Netarsudil)
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Description
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Fact Table
| Fact Table | |
|---|---|
| Formula | C28H27N3O7 |
| License | FDA approved (2017) |
| Bioavailability | Not applicable (topical ophthalmic use; minimal systemic exposure) |
| Legal status | Prescription only (Rx) |
| Chemical Name | (S)-4-(3-amino-1-(isoquinolin-6-yloxy)propyl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide dimesylate |
| Elimination half-life | ~16–17 hours (systemic, netarsudil metabolite AR-13503) |
| Dosage (Strength) | 0.02% ophthalmic solution; 1 drop in affected eye(s) once daily in the evening |
| Pregnancy | Limited human data; use only if potential benefit justifies potential risk |
| Brands | Rhopressa (Aerie Pharmaceuticals) |
| Protein binding | Not well characterized (minimal systemic levels) |
| PubChem CID | 49846507 |
| MedlinePlus | a618020 |
| ChEBI | 134722 |
| ATC code | S01EX05 |
| DrugBank | DB11739 |
| KEGG | D11241 |
| Routes of administration | Ophthalmic (eye drops) |
Rhopressa (Netarsudil) helps drain aqueous humor (the fluid inside the eye) more effectively in people with open-angle glaucoma or ocular hypertension. While this effectively relieves eye pressure, the exact mechanism of this medication remains unclear.
Rhopressa helps aqueous humor (fluid in the eye) drain better, which reduces eye pressure. Despite the medication's effectiveness, the exact way it works remains unclear.
Directions
Want to buy Rhopressa eye drops (ophthalmic solution) at a low price? Look no further than CanPharm for Rhopressa discounts and savings. This medication is available as an ophthalmic solution in 0.02% strength. When using Rhopressa eye drops, following the steps below:
- Use only as prescribed by your doctor.
- Apply once daily (usually evenings) directly into the affected eye.
- Do not use more than one daily dose per affected eye.
- If you miss a dose, continue with your next scheduled one.
- Use this medication long-term, as long as prescribed by your provider.
- Allow at least 5 minutes between Rhopressa and other medications addressing eye pressure.
Ingredients
The active ingredient in Rhopressa is netarsudil (0.02% strength).
Cautions
- Rhopressa can cause swelling of the eye's surface (Epithelial Corneal Edema), especially in people with prior corneal issues or after certain eye surgeries. If you experience eye pain or vision that worsens or blurs, notify your eye doctor immediately.
- Like other eye drops, Rhopressa poses a risk for eye infections (bacterial keratitis) if the dropper tip touches the eye, fingers, or other surfaces. This particularly applies to patients with corneal disease or eye surface injury. Ensure the bottle tip is kept clean and avoid touching the eye while using this medication.
- Remove contact lenses before using Rhopressa and wait for 15 minutes after application to place them back.
- You may experience general eye irritation when using Rhopressa, including ongoing redness, discomfort or vision changes. If any of these occur during use, inform your eye doctor.
- This medication is not approved for use in children.
Contraindications
According to the FDA, there are no known contraindications of Rhopressa. Precautions still apply.
Side Effects
Common side effects:
- Eye redness
- Swirl-shaped markings on the cornea (corneal verticillata)
- Stinging or pain during use
- Small blood spots on the white of the eye
- Redness at the application site
- Mild eye irritation of the eye surface or eyelids
- Staining of the eye surface or eyelids
- Watery eyes
Serious side effects:
- Corneal swelling
- Eye irritation
- Worsened vision
- Severe pain
Report any concerning, ongoing or worsening side effects to your healthcare provider. Keep in mind that you may experience adverse effects not mentioned in this list, as it is not exhaustive.
If you're looking to buy Rhopressa eye drops and have a valid prescription, Canada Drugs Direct is the right place for you.
Learn about the Rhopressa eye drop price and available discounts today!
Frequently Asked Questions about Rhopressa (Netarsudil)
What is Rhopressa (Netarsudil) used for?
Rhopressa is a prescription eye drop used to lower elevated intraocular pressure in people with open-angle glaucoma or ocular hypertension. Reducing eye pressure helps prevent damage to the optic nerve and vision loss.
How does Rhopressa work?
Rhopressa works by inhibiting Rho kinase and the norepinephrine transporter, which increases fluid outflow through the eye’s trabecular meshwork and reduces fluid production, leading to lower eye pressure.
How is Rhopressa typically used?
Rhopressa is usually applied as one drop in the affected eye once daily in the evening. It is important to use it consistently at the same time each day to maintain effective pressure control.
What are the most common side effects of Rhopressa?
The most common side effects include redness of the eye, mild eye discomfort or pain, corneal deposits, blurred vision, and increased tearing. Eye redness is the most frequently reported effect.
Can Rhopressa cause eye redness to be permanent?
The eye redness associated with Rhopressa is usually temporary and tends to lessen over time with continued use. It typically resolves after stopping the medication.
Can Rhopressa be used with other glaucoma eye drops?
Rhopressa can be used with other glaucoma medications if prescribed. When using multiple eye drops, they should be spaced several minutes apart to avoid washing one medication out of the eye.
Who should not use Rhopressa?
Rhopressa may not be suitable for individuals with known hypersensitivity to netarsudil or any component of the formulation. A healthcare provider should evaluate its use in people with eye infections or recent eye surgery.
Does Rhopressa affect vision?
Rhopressa may cause temporary blurred vision or visual disturbances after application. These effects are usually mild and short-lived but can affect activities like driving immediately after use.
Is Rhopressa safe for long-term use?
Rhopressa is intended for long-term use in managing eye pressure. Regular eye exams are important to monitor effectiveness and detect any ongoing side effects during extended treatment.
How should Rhopressa be stored?
Rhopressa should be stored at room temperature and protected from light. The bottle should be kept tightly closed when not in use and not used past the expiration date.
