Rituxan (Rituximab)

Rituxan (rituximab) is a monoclonal antibody used primarily to treat various types of cancer, including non-Hodgkin's lymphoma and chronic lymphocytic leukemia. It is also used in the treatment of autoimmune diseases such as rheumatoid arthritis. Rituxan works by targeting the CD20 protein found on the surface of B cells, thereby helping to destroy these cells. It is intended for use under the supervision of a healthcare professional and is usually administered in a clinical setting.

Before you buy Rituxan, it is crucial that you talk to your healthcare provider about potential side effects and Rituxan infusion cost.

Directions

For Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia:

Rituxan is administered by intravenous infusion. The dosage and schedule may vary depending on the specific condition, the patient's medical history, and response to treatment. Typically, it is given as part of a treatment regimen that includes other chemotherapeutic agents.

For Rheumatoid Arthritis:

Patients receive Rituxan in two separate doses of 1000 mg each, administered as an intravenous infusion separated by a two-week interval, in combination with methotrexate. Treatment cycles can be repeated every 24 weeks, or based on clinical evaluation, but not sooner than every 16 weeks.

It is crucial that patients receive pre-medication with an antihistamine and acetaminophen prior to infusion to reduce the risk of infusion reactions.

Ingredients

Rituxan uses rituximab as its active ingredient.

Cautions

Rituxan therapy should be administered under the strict supervision of a qualified healthcare professional in a facility equipped to manage severe infusion reactions. Patients should be monitored closely for infusion-related reactions, which are most common during the first infusion.

Patients with a history of heart conditions should discuss potential risks with their doctor, as Rituxan can cause cardiac complications. It is also contraindicated in patients with known severe, life-threatening allergic reactions to rituximab or any of the components of the formulation.

Before starting treatment, patients must be screened for hepatitis B virus infection as reactivation can occur in individuals who are carriers of the virus. This can lead to severe liver problems or death.

Pregnant women, women planning to become pregnant, or nursing mothers should discuss the potential risks and benefits of Rituxan with their healthcare provider, as it can be harmful to the fetus or the nursing infant.

Interactions

Rituxan can interact with several other medications, potentially altering their effects. It is very important to inform the healthcare provider of all medications being taken, including over-the-counter drugs, vitamins, and herbal supplements. Particular caution should be used when combining Rituxan with drugs known to affect the immune system or with other chemotherapeutic agents, due to an increased risk of infections or adverse reactions. Live vaccines should be avoided during treatment with Rituxan and for several months afterward, as the medication may affect the immune system's ability to respond to the vaccine.

Side Effects

Common side effects of Rituxan include:

• Infusion reactions (fever, chills, rash, itching, difficulty breathing)
• Infections (bacterial, viral, fungal)
• Body aches, fatigue, and headache
• Abdominal pain and digestive disturbances
• Changes in blood counts