Rukobia (Fostemsavir)
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Description
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Fact Table
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| Formula | C23H29N6O9PS (Fostemsavir tromethamine salt) |
| License | FDA Approved |
| Bioavailability | 20% (Treated with food) |
| Legal status | Prescription Drugs |
| Chemical Name | Fostemsavir |
| Elimination half-life | 7 hours (metabolite temsavir) |
| Dosage (Strength) | 600 mg (extended-release tablets) |
| Pregnancy | Consult a healthcare provider |
| Brands | Rukobia |
| Protein binding | 99% (temsavir metabolite) |
| PubChem CID | 5274348 |
| MedlinePlus | Available |
| ChEBI | Not listed specifically |
| ATC code | J05AX28 |
| DrugBank | DB12466 (Fostemsavir) |
| KEGG | D10770 (Fostemsavir) |
| Routes of administration | Oral |
Rukobia (fostemsavir) is an innovative antiretroviral medication specifically designed for adults with multidrug-resistant HIV-1 infection for whom it is otherwise difficult to form a suppressive antiviral regimen. Approved by the FDA, Rukobia offers a novel mechanism of action by targeting the gp120 component of the viral envelope, thereby blocking the virus’s entry into cells.
This medication is particularly significant for patients who have tried multiple HIV treatments without success, providing a new hope for effectively managing their condition. Rukobia is available in tablet form, each containing 600 mg of fostemsavir. Before you buy Rukobia, it is crucial that you talk to your healthcare provider about potential side effects and Rukobia cost.
Directions
The recommended dosage of Rukobia is one 600 mg tablet taken orally twice daily. Take Rukobia tablets whole with water without chewing, crushing, or splitting the tablets. Rukobia can be taken with or without food. Continuation of Rukobia should be under the supervision of a healthcare provider experienced in the management of HIV-1 infection. Regular follow-up appointments are essential to monitor the effectiveness and any potential side effects of the treatment.
Ingredients
Active Ingredient: Fostemsavir tromethamine.
Cautions
Inform your doctor about any past allergic reactions to medications, particularly to any component of Rukobia.
The safety of Rukobia during pregnancy and breastfeeding has not been established.
Patients with a history of liver disease or those with hepatic impairment should use Rukobia with caution.
Interactions
Rukobia should not be co-administered with certain drugs due to the potential for significant interactions that can affect the effectiveness of the treatment or increase the risk of serious side effects. These include rifampin and other rifamycins, anticonvulsants such as phenytoin and phenobarbital and St. John's Wort. Always inform your healthcare provider about all the medications you take, including prescription, over the counter, herbal supplements, and vitamins.
Side Effects
Common Side Effects of Rukobia 600 mg are nausea, headache, and diarrhea. These are generally mild and often resolve as the body adjusts to the medication.
Frequently Asked Questions about Rukobia (Fostemsavir)
What is Rukobia used for?
Rukobia (fostemsavir) is used with other antiretroviral medicines to treat Human Immunodeficiency Virus (HIV-1) infection in adults who have received several anti-HIV-1 regimens in the past, and have HIV-1 virus that is resistant to many antiretroviral medicines, and are failing their current antiretroviral therapy.
What are the side effects of Rukobia?
The most common side effects of Rukobia include nausea, diarrhea, headache, abdominal pain, dyspepsia, fatigue, rash, and sleep disturbance. Serious side effects include changes in the immune system, heart rhythm problems (QTc prolongation), and changes in liver function blood tests results.
What route of administration is Rukobia?
Rukobia is administered orally. The recommended dosage is one 600-mg tablet taken orally twice daily with or without food.
What is another name for Rukobia?
Another name for Rukobia is fostemsavir.
When was Rukobia approved?
Rukobia was approved by the U.S. Food and Drug Administration (FDA) on July 2, 2020.
What is the mechanism of action of Rukobia?
Rukobia (fostemsavir) attaches directly to gp120 on the surface of HIV-1 virions, near the CD4 + attachment site. This action prevents the initial interaction between the virus and host immune cells, thus preventing the first step of viral entry.
Can fostemsavir be crushed?
Fostemsavir tablets should be swallowed whole. They should not be chewed, crushed, or split before swallowing.
What cardiac-related issues have been associated with high doses of fostemsavir?
High doses of fostemsavir are likely to result in QTc prolongation, a type of heart rhythm disorder. Elderly patients are more likely to have age-related heart problems, which may require caution in the dose for patients receiving this medicine.
