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Santyl Ointment (Collagenase)

Prescription requiredOnly Available By Prescription
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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Santyl Ointment, also known as collagenase ointment, is a prescription medication used in wound care. Its main purpose is to help debride wounds, particularly chronic skin ulcers, and severely burned areas. Santyl works by breaking down certain proteins in necrotic (dead) tissue, helping to remove this tissue from the wound and thereby promoting healing.

Before you buy Santyl Ointment, you should consult with a healthcare provider to ensure it's the right treatment for your specific wound condition, understand the proper usage, potential side effects and Santyl ointment price.

Fact Table
Formula C1377N239O404S7
License FDA-Approved
Bioavailability Not applicable (topical administration)
Legal status Prescription drug
Chemical Name Collagenase - Clostridiopeptidase A
Elimination half-life Not applicable for topical medications
Dosage (Strength) 250u / g
Pregnancy Consult a doctor
Brands Santyl
Protein binding Not applicable for topical medications
PubChem CID 441476
MedlinePlus a601121
ChEBI 82768
ATC code D03BA02
DrugBank DB00042
KEGG D03736
Routes of administration Topical

Buy Santyl Ointment (Collagenase) online from online Canadian Pharmacy |


Use this medication only on the skin, normally once daily or as per your doctor's instructions.

If the dressing becomes dirty, you may need to apply Santyl more often.

Before application, wash your hands and clean the wound as directed by your doctor. You may use solutions like hydrogen peroxide, normal saline, or Dakin's solution for cleaning.

If instructed to use an antibiotic powder, apply it before the Santyl ointment.

Use a wooden spatula or gauze pad to apply the ointment directly on the wound, then secure with a bandage.

Keep the ointment away from your eyes and apply only within the affected area.

Ensure to wash your hands thoroughly after application.


The primary component in Santyl Ointment is a protein-digesting enzyme known as collagenase.


Inform your healthcare provider if you have any known allergies to collagenase or any other medications.

If you suspect the wound is infected, characterized by increased redness, warmth, swelling, or pus, contact your healthcare provider promptly.

This medication is for topical use only. Avoid contact with eyes, inside the mouth, and other mucous membranes.

While it's not known if Santyl can harm an unborn baby or if it passes into breast milk, it's always important to inform your healthcare provider if you're pregnant, planning to become pregnant, or breastfeeding.

Regularly monitor the progress of the wound and report any changes to your healthcare provider.


This ointment may have interactions with antiseptic skin solutions, especially those containing heavy metals like lead, mercury, or silver.

Side Effects

Santyl Ointment can cause mild side effects like redness, pain, or irritation at the application site. Rarely, it may cause an allergic reaction with symptoms like hives, difficulty breathing, or facial swelling. If you have an allergic reaction, reach out to your healthcare provider without delay.

Frequently Asked Questions about Santyl

When to stop using Santyl on the wound?

Stop using Santyl when the dead tissue in the wound is removed and healthy tissue is visible, if you're experiencing side effects, or if your healthcare provider advises you to. You should always seek advice from your healthcare professional for direction.

Why is Santyl so expensive?

Santyl is expensive due to costs related to research and development, regulatory approval, high-quality manufacturing, and patent protection. Also, lack of a generic alternative allows the manufacturer to maintain higher prices. You can save your money on prescriptions when you buy santyl ointment online from CanPharm.

How long does it take for Santyl to work?

Santyl's effectiveness varies based on the wound and individual health factors. Typically, improvement may be seen within a few days to a week, but complete healing can take weeks to months.

Is Santyl over the counter?

No, Santyl is not available over the counter. It is a prescription medication and should only be used under the supervision of a healthcare provider.

Can you use Santyl and Calcium alginate together?

There is no specific contraindication against using Santyl and calcium alginate dressings together. A study suggested calcium alginate does not significantly impact Santyl's activity.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.