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Skyrizi (risankizumab-rzaa)

Prescription requiredOnly Available By Prescription
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Skyrizi is a prescription plaque psoriasis treatment medication administered as an injection for moderate to severe cases with raised, scaly skin patches being more pronounced. It is often recommended by doctors when used in light therapy for psoriasis or systemic therapy for plaque psoriasis. Skyrizi may also be for psoriatic arthritis or for Crohn's disease. For any treatment application the active ingredient in Skyrizi medication - Risankizumab-Rzaa - serves as an antibody drug that binds to the IL23 inflammatory protein in the body and suppresses its activity. 

Fact Table
Formula C6428H9912N1694O2010S46
License FDA approved
Bioavailability Not applicable (biologic administered via injection)
Legal status Prescription Drugs
Chemical Name Risankizumab-rzaa
Elimination half-life Approximately 28 days
Dosage (Strength) 150 mg per ml, administered as a subcutaneous injection
Pregnancy Category B (no evidence of risk in animal studies)
Brands Skyrizi
Protein binding Not applicable to monoclonal antibodies
PubChem CID Not available
MedlinePlus Not listed
ChEBI Not available
ATC code L04AC17
DrugBank DB14018
KEGG D11056
Routes of administration Subcutaneous injection

Buy Skyrizi (Risankizumab-Rzaa) online from online Canadian Pharmacy |


Skyrizi dosing has a standardized schedule where a single injection is given during the 1st week of your treatment plan, and then a 2nd injection follow-up injection is given after four weeks. After this 1 Skyrizi injection and injection will then be administered once every 12 weeks (3 months).

Injection site can be the front of your thighs (at the top part of your leg between the knee and hip) or you may also inject the lower part of your abdomen but make sure the injection is at least 2” away from navel. Sitting in a chair when administering the injection is advised.


The active ingredient in Skyrizi is Risankizumab-Rzaa.


Let your doctor know of any history of liver problems, tuberculosis, or recurring infections before beginning on Skyrizi medication.

Using Skyrizi may not be possible for those with an upcoming vaccination scheduled.

Use this medication when pregnant or breastfeeding only if a doctor approves that course of action.

Store SKYRIZI in the refrigerator between 36°F to 46°F (2°C to 8°C).

Do not freeze or shake this medication.

Be aware of expiry date for medication.


Negative drug interactions between Skyrizi and other Rx medications are possible, including other immunosuppressants and particularly with live vaccines. Let your doctor know of all medications and supplements you are currently taking before getting a prescription and proceeding to buy Skyrizi online.

Side Effects

Side effects from using Skyrizi may occur, and some people may experience upper respiratory infections, headache, fatigue, injection site reactions, fungal skin infections, injection site reactions, low red blood cells (anemia), fever, back pain, or urinary tract infections. If side effects are seen you can discontinue use and meet with your doctor again to discuss your plaque psoriasis treatment alternatives.

Frequently Asked Questions about Skyrizi

What is Skyrizi used for?

Skyrizi is used to treat moderate to severe plaque psoriasis and active psoriatic arthritis in adults.

How is Skyrizi administered?

Skyrizi is given as a subcutaneous injection with dosages at the beginning of treatment, followed by maintenance doses.

Can I receive vaccinations while on Skyrizi?

Live vaccines should be avoided during treatment with Skyrizi. Discuss all vaccinations with your healthcare provider.

What should I do if I miss a dose of Skyrizi?

If a dose is missed, administer it as soon as possible and then resume your normal dosing schedule. However, consult your healthcare provider for specific advice.

Can Skyrizi cure psoriasis or psoriatic arthritis?

Skyrizi is not a cure for psoriasis or psoriatic arthritis, but it can help manage symptoms and improve quality of life.

Are there any foods I should avoid while taking Skyrizi?

There are no specific food restrictions while taking Skyrizi, but a healthy diet can help manage symptoms of psoriasis and psoriatic arthritis.

How quickly does Skyrizi work?

Some patients may see improvements within 16 weeks of starting treatment, but response times can vary.

What are the serious side effects of Skyrizi?

Serious side effects include serious infections, allergic reactions, and possibly other immune-mediated conditions.

Can Skyrizi be used during pregnancy?

Discuss potential risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant.

How should I store Skyrizi?

Skyrizi should be stored in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Keep the medication in its original container and protect it from light.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.