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Only Available By Prescription
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Synjardy XR is a prescription Type 2 diabetes treatment medication that is a combination of 2 active ingredients and is known to produce lower A1c hemoglobin test scores and lower fasting blood sugar levels for many diabetics who don't have the same level of effectiveness from other Rx medications geared to treat Type 2 diabetes. It combines the effectiveness of biguanide medications with that of SGLT2 inhibitors for better blood glucose control. This XR (extended release) version of Synjardy also has the advantage of only needing to be taken 1x daily.
You can buy Synjardy XR with a prescription, and your best price on it will be when you order medication online from Canada and Canpharm.
| Fact Table | |
|---|---|
| Formula | * Empagliflozin: C23H27FO7 * Metformin HCl: C4H11N5·HCl |
| License | US FDA (and others) |
| Bioavailability | * Empagliflozin: ~78% * Metformin: 50-60% (Extended Release) |
| Legal status | Prescription (Rx) |
| Chemical Names | * Empagliflozin * Metformin hydrochloride |
| Elimination half-life | * Empagliflozin: ~12 hours * Metformin XR: ~17 hours |
| Dosage (Strength) | Various combinations available (e.g., 5mg empagliflozin/1000mg metformin XR) |
| Pregnancy | Not recommended during 2nd/3rd trimesters |
| Brands | Synjardy XR, Synjardy |
| Protein binding | * Empagliflozin: 86.2% * Metformin: Negligible |
| PubChem CID | * Empagliflozin: 645248 * Metformin: 4091 |
| MedlinePlus | Not Assigned |
| ChEBI | * Empagliflozin: CHEBI:135386 * Metformin: CHEBI:15862 |
| ATC code | A10BD20 |
| DrugBank | * Empagliflozin: DB09084 * Metformin: DB00331 |
| KEGG | * Empagliflozin: D09949 * Metformin: D00186 |
| Routes of administration | Oral (tablet) |
Your doctor will specify which of the Synjardy XR dosing quantities you should be using between the 5 / 500mg, 5 / 1000mg, 12.5mg / 500mg, and 12.5mg / 1000mg strengths
Take one tablet whole with food 1x a day in the morning. Do not split, crush, dissolve, or chew tablets
Your doctor may stipulate you take a higher starting dose, and then move to a lower maintenance dose depending on how well you begin to control your blood glucose
The active ingredients in Synjardy XR are Empagliflozin and Metformin
Tell your doctor if you have any history of lactic acidosis, renal impairment, other liver or kidney problems, genital yeast infections, or alcohol abuse before starting on Synjardy XR
You should also tell your doctor is you have any surgeries scheduled in the near future
Medication should be stored at room temperature (77° F and 25° C) and in a tightly sealed container away from light
Be aware of medication expiry date
There is the possibility of negative drug interactions between Synjardy XR and other Rx medications, including amlodipine / aspirin / atorvastatin / fenofibrate / gabapentin / hydrochlorothiazide / levothyroxine / lisinopril / losartan / metformin / metoprolol / montelukast / omeprazole / Ozempic (semaglutide) / rosuvastatin / tamsulosin / Trulicity (dulaglutide) / Vitamin D3 (cholecalciferol)
Tell your doctor of all medications you are currently taking before receiving a prescription and proceeding to buy Synjardy XR online
Synjardy XR side effects are uncommon, but some users may experience bladder pain, bloody or cloudy urine, blurred vision, chills, confusion, appetite loss, dizziness, urinary urges, back or side pain, muscle cramps, nausea, or fatigue. If Synjardy XR side effects are experienced you may want to discontinue use and speak with your doctor again regarding Type 2 diabetes treatment alternatives.
What is Synjardy XR?
Synjardy XR is a prescription medicine that contains two diabetes medicines, empagliflozin (JARDIANCE) and metformin HCl.
Who can use Synjardy XR?
Synjardy XR can be used along with diet and exercise to improve blood sugar in adults with type 2 diabetes.
Can children use Synjardy XR?
No, Synjardy XR is not recommended for children. However, Synjardy (not XR) can be used by children who are 10 years of age and older with type 2 diabetes.
How does Synjardy XR work?
Empagliflozin works by helping the kidneys get rid of glucose from your bloodstream. Metformin works by preventing sugar and sodium (salt) from absorbing back into your body.
What are the benefits of Synjardy XR?
Synjardy XR, along with diet and exercise, can help lower your A1C and fasting blood sugar.
Can Synjardy XR reduce the risk of cardiovascular death?
While JARDIANCE has been shown to reduce the risk of cardiovascular death, the effectiveness of SYNJARDY XR, the combination of JARDIANCE and metformin, on reducing the risk of cardiovascular death has not been studied.
What are the side effects of Synjardy XR?
Synjardy XR can cause serious side effects, including lactic acidosis (a build-up of lactic acid in the blood) that can cause death.
Who should not use Synjardy XR?
People with moderate to severe kidney problems, liver problems, or who drink a lot of alcohol should not use Synjardy XR.
What should I do if I experience symptoms of lactic acidosis while taking Synjardy XR?
If you experience symptoms of lactic acidosis such as feeling very weak and tired, unusual sleepiness, unusual muscle pain, feeling cold, trouble breathing, feeling dizzy, or unexplained stomach problems, stop taking Synjardy XR and call your healthcare provider right away or go to the nearest hospital emergency room.
Can I stop taking Synjardy XR if my blood sugar improves?
No, it’s important to continue taking SYNJARDY XR even after you’ve started seeing improvements in your A1C and blood sugar.
