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Only Available By Prescription
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
| Fact Table | |
|---|---|
| Formula | C274H411N65O81 |
| License | FDA approved |
| Bioavailability | ~60% (subcutaneous injection) |
| Legal status | Prescription only |
| Chemical Name | Insulin degludec recombinant |
| Elimination half-life | ~25 hours (duration of action >42 hours) |
| Dosage (Strength) | 100 units/mL (U-100), 200 units/mL (U-200) |
| Pregnancy | Category C – Consult doctor |
| Brands | Tresiba |
| Protein binding | >99% |
| PubChem CID | 86278389 |
| MedlinePlus | a615033 |
| ChEBI | 134730 |
| ATC code | A10AE06 |
| DrugBank | DB09532 |
| KEGG | D10317 |
| Routes of administration | Subcutaneous injection |
How do I know if Tresiba is working properly?
You should see improvement in fasting blood glucose levels and overall blood sugar stability. Your HbA1c should improve over time with proper use.
What are signs of low blood sugar on Tresiba?
Common signs include:
Shakiness
Sweating
Confusion
Dizziness
Hunger
Severe cases may cause seizures or unconsciousness and require glucagon or emergency help.
Can I drink alcohol while using Tresiba?
Caution is advised. Alcohol can lower blood sugar and increase the risk of hypoglycemia, especially when combined with insulin. Monitor your levels closely if drinking.
Does Tresiba interact with other medications?
Yes. Some drugs (e.g., beta-blockers, diuretics, steroids, oral diabetes meds) can interact with insulin. Always inform your provider of all medications and supplements.
How is Tresiba different from Toujeo or Levemir?
Tresiba lasts over 42 hours
Toujeo lasts around 36 hours
Levemir lasts 12–24 hours
Tresiba has the longest duration and the most flexible dosing schedule.
Can I travel with Tresiba?
Yes. Keep it in your carry-on, not checked luggage. Use an insulated case to avoid heat or freezing. Carry a prescription and medical note when flying.
Does Tresiba have a peak action time?
No. Tresiba has a flat, peakless profile, meaning it releases insulin steadily with minimal day-to-day variation — reducing hypoglycemia risk.
Is Tresiba expensive? Are there savings options?
Yes, it can be costly. Manufacturer savings cards, patient assistance programs, and biosimilar alternatives (when available) may help reduce costs.
How long can I keep Tresiba once opened?
Once opened and kept at room temperature, Tresiba can be used for up to 56 days (8 weeks), making it more durable than many other insulins.
Should I test my blood sugar while using Tresiba?
Yes. Regular blood glucose monitoring is essential, especially during dose adjustments, illness, or changes in activity or diet.
