Vemlidy (Tenofovir Alafenamide)
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Description
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Fact Table
| Fact Table | |
|---|---|
| Formula | C21H29O5N6P |
| License | FDA approved |
| Bioavailability | High (under fasted conditions) |
| Legal status | Prescription Drug |
| Chemical Name | Tenofovir Alafenamide Fumarate |
| Elimination half-life | Approximately 0.5 hours |
| Dosage (Strength) | 25 mg tablets |
| Pregnancy | Consult healthcare provider |
| Brands | Vemlidy |
| Protein binding | 80% (plasma) |
| PubChem CID | 44468282 |
| MedlinePlus | a617040 |
| ChEBI | 87082 |
| ATC code | J05AF13 |
| DrugBank | DB09299 |
| KEGG | D10755 |
| Routes of administration | Oral |
Vemlidy (tenofovir alafenamide) is a prescription medication approved for the treatment of chronic hepatitis B virus (HBV) infection in adults with compensated liver disease. Vemlidy belongs to a class of antiviral drugs known as nucleotide reverse transcriptase inhibitors (NRTIs), which help prevent the virus from multiplying and can reduce the amount of the virus in the body. Vemlidy offers the advantage of being effective at a lower dose compared to other tenofovir drugs, potentially leading to fewer renal and bone side effects.
Before you buy Vemlidy, it is crucial that you talk to your healthcare provider about potential side effects and Vemlidy price.
Directions
Vemlidy should be taken exactly as prescribed by your healthcare provider. The typical dosage is one tablet taken orally once daily with food. It is crucial to follow the dosing schedule closely and not to alter the dose or discontinue the medication without consulting your doctor. Regular follow-up appointments are necessary to monitor your liver function and the effectiveness of the treatment.
Ingredients
Vemlidy uses tenofovir alafenamide as its active ingredient.
Cautions
Patients with a history of liver disease or those who are co-infected with HIV should use Vemlidy with caution. Regular liver function tests are recommended to monitor for potential worsening of liver disease.
Since tenofovir alafenamide can affect renal function, kidney function tests should be performed periodically during treatment.
Tenofovir drugs have been associated with bone loss; therefore, patients at risk of osteoporosis or who have existing bone health issues should discuss this with their healthcare provider.
Interactions
Vemlidy can interact with other medications, which can alter how it or the other medications work. You should disclose all medications you are using, including prescription drugs, over-the-counter products, and herbal supplements, to your healthcare provider. Notable interactions include antiretrovirals, NSAIDs and supplements containing calcium or iron.
Side Effects
Like all medications, Vemlidy can cause side effects, though not everyone experiences them. Common side effects include:
- Nausea
- Fatigue
- Headache
- Stomach pain
- Dizziness
Frequently Asked Questions about Vemlidy
Why is Vemlidy so expensive?
The high cost of Vemlidy is due to a variety of factors including the costs of research and development, manufacturing, and marketing. The lack of a generic version also contributes to its high price.
What is Vemlidy used for?
Vemlidy (tenofovir alafenamide) is an antiviral medication used to treat chronic hepatitis B virus (HBV) infection in adults and children aged 6 years and older.
Can Vemlidy cure hepatitis B?
While Vemlidy can suppress the hepatitis B virus and improve liver condition, it does not typically lead to a complete cure. Long-term treatment is often required.
How does Vemlidy work?
Vemlidy works by inhibiting the replication of the hepatitis B virus. It is converted inside liver cells to its active form, which incorporates into the viral DNA and terminates the DNA chain.
How long do you take Vemlidy?
The duration of Vemlidy treatment varies and can last several years. It is typically taken until the healthcare provider determines that treatment can be stopped.
Is there a generic for Vemlidy?
A generic version of Vemlidy has been approved by the FDA, but it may not be commercially available due to drug patents and/or drug exclusivity.
Is Vemlidy an immunosuppressant?
No, Vemlidy is not an immunosuppressant. It is an antiviral medication that works by inhibiting the replication of the hepatitis B virus.
When to stop Vemlidy?
Vemlidy should not be stopped without consulting a healthcare provider. Stopping Vemlidy can lead to a flare-up of hepatitis B. Regular monitoring and blood tests are required after stopping the medication.
