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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Venclexta ) inhibits a certain protein in cancer cells (abnormal lymphocytes produced in chronic lymphocytic leukemia) that helps keep those cells alive and makes them resistant to chemotherapy. Venetoclax binds to this protein, which helps kill the cancerous lymphocytes in blood and bone marrow. Venclexta is a prescription medicine used to treat chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL) in adults with or without 17p deletion (a specific genetic marker). Venetoclax is sometimes used in combination with rituximab to treat these conditions. Venclexta is also used in combination with azacitidine, decitabine, or low-dose cytarabine to treat acute myeloid leukemia.This combination is for use in adults who are 75 years or older, or who cannot use standard chemotherapy due to other medical conditions.
Take Venclexta exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects. Take Venclexta with food and water, at the same time each day. Do not crush, chew, or break a tablet. Swallow the tablet whole. If you vomit shortly after taking Venclexta, do not take another tablet. Take your next dose as scheduled the next day. To prevent certain side effects, drink 6 to 8 glasses of water daily for 2 days before you start taking Venclexta. Also drink 6 to 8 glasses of water on the day you first take this medicine, and whenever your dose is changed. You may need frequent medical tests and your cancer treatments may be delayed based on the results. Do not stop using this medicine without first asking your doctor. Store tablets in their original container at room temperature, away from moisture and heat. Do not put the tablets into a daily pill box.
The active ingredient in Venclexta is venetoclax.
Call your doctor at once if you have a fever, chills, joint or muscle pain, tiredness, confusion, shortness of breath, fast or slow heartbeats, nausea, vomiting, dark or cloudy urine, or a seizure (convulsions). Drink 6 to 8 full glasses of water each day to help prevent these side effects. Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Get emergency medical help if you have signs of an allergic reaction to Venclexta: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: • symptoms of sepsis - confusion, severe drowsiness, rapid breathing, feeling very ill; • signs of pneumonia - cough with yellow or green mucus, stabbing chest pain, wheezing, trouble breathing; • low blood cell counts - fever, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed; or • signs of tumor cell breakdown - chills, joint or muscle pain, feeling tired or short of breath, fast or slow heartbeats, nausea, vomiting, dark or cloudy urine, or seizure (convulsions). Your cancer treatments may be delayed or permanently discontinued if you have certain side effects. Common Venclexta side effects may include: • stomach pain, nausea, vomiting, diarrhea, constipation; • feeling tired or short of breath; • low blood pressure, feeling dizzy or lightheaded; • muscle and joint pain; • swelling in your arms, legs, hands, and feet; • fever, low blood cell counts; • pneumonia, sepsis; • mouth pain; • rash; or • cold symptoms such as stuffy nose, sneezing, sore throat, cough. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.