Wixela (Fluticasone / Salmeterol)
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Fact Table
| Fact Table | |
|---|---|
| Formula | C27H44F2O5 (Fluticasone) / C25H37NO4 (Salmeterol) |
| License | FDA approved |
| Bioavailability | Low for oral administration (first-pass metabolism), higher with inhalation |
| Legal status | Prescription Drugs |
| Chemical Name | Fluticasone propionate / Salmeterol xinafoate |
| Elimination half-life | Fluticasone: ~7.8 hours / Salmeterol: ~5.5 hours |
| Dosage (Strength) | 100/50 µg, 250/50 µg, or 500/50 µg per inhalation (Fluticasone/Salmeterol) |
| Pregnancy | Use with caution; benefits should outweigh risks |
| Brands | Wixela Inhub, Advair Diskus |
| Protein binding | Fluticasone: ~91% / Salmeterol: ~96% |
| PubChem CID | 5311101 (Fluticasone) / 6918314 (Salmeterol) |
| MedlinePlus | a699063 (Advair Diskus) |
| ChEBI | 47974 (Fluticasone propionate) / 50504 (Salmeterol xinafoate) |
| ATC code | R03AK06 |
| DrugBank | DB00588 (Fluticasone) / DB00938 (Salmeterol) |
| KEGG | D07937 (Fluticasone) / D02165 (Salmeterol) |
| Routes of administration | Inhalation |
Wixela is a generic form of the well-known combination inhaler containing fluticasone propionate and salmeterol. This medication is designed to provide significant relief from respiratory conditions such as asthma and COPD. Wixela comes in a specially designed inhaler, which helps patients to administer the medication directly to the lungs for effective symptom management. This inhaler is available in different strengths to accommodate varying medical needs and dosing requirements. Each strength provides a measured dose of fluticasone propionate, a corticosteroid that reduces inflammation, and salmeterol, a long-acting beta-agonist that relaxes muscles in the airways to improve breathing.
Before you buy Wixela inhaler, it is crucial that you talk to your healthcare provider about potential side effects and Wixela inhaler price.
Directions
To ensure optimal effectiveness and safety, it is crucial to use Wixela inhaler dose exactly as prescribed by your healthcare provider. It is important not to exceed the prescribed dose. Regular use at the same time each day enhances the effectiveness of the medication.
Ingredients
The active ingredients in Wixela are Fluticasone Propionate and Salmeterol Xinafoate.
Cautions
Severe cardiovascular disorders, heart rhythm abnormalities, or who are sensitive to beta-adrenergic agonists.
Conditions that could be exacerbated by hypokalemia or hyperglycemia.
A known immune system compromise, as immunosuppressive effects are a risk with any steroid medication.
It is also not recommended for the primary treatment of acute asthma episodes or acute bronchospasms.
Interactions
Wixela can potentially interact with several other medications, which may enhance or diminish its effects like beta-blockers, diuretics and xanthine derivatives and MAO inhibitors and tricyclic antidepressants. Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs and herbal supplements.
Side Effects
While Wixela is effective in controlling asthma and COPD, it can cause side effects in some patients. Common side effects include:
- Headache
- Throat irritation
- Hoarseness
- Candidiasis of the mouth and throat (thrush)
- Musculoskeletal pain
- Increased heart rate
- Tremors
Frequently Asked Questions about Wixela (Fluticasone Propionate and Salmeterol)
What is Wixela?
Wixela is a prescription medication that belongs to a class of drugs called combination inhaled corticosteroids and long-acting beta agonists (LABA). It contains two active ingredients, fluticasone propionate and salmeterol.
What is Wixela used for?
Wixela is used to manage the symptoms of asthma and chronic obstructive pulmonary disease (COPD). It helps reduce airway inflammation and improve lung function.
How to use Wixela inhaler?
Wixela is inhaled by mouth twice daily. It’s important to not exhale into the device, and to rinse your mouth with water after each use.
How does Wixela work?
Wixela works by reducing airway inflammation and improving lung function. Fluticasone propionate reduces inflammation in the airways, while salmeterol relaxes the muscles around the airways, allowing them to open up and improve airflow.
Is Wixela a steroid?
Yes, one of the active ingredients in Wixela, fluticasone propionate, is a steroid that lowers inflammation in the lungs.
Does Wixela cause weight gain?
Yes, Wixela may cause some weight gain.
How long does Wixela stay in your system?
The inhaler should be discarded when the dose counter reaches “0,” 1 month after opening the foil pouch, or after the expiration date, whichever comes first.
Does Wixela raise blood pressure?
Wixela may increase your blood pressure. It’s recommended to monitor your blood pressure and speak to your doctor if your blood pressure is high.
How long does Wixela take to work?
Improvement in asthma control following inhaled administration of Wixela can occur within 30 minutes of beginning treatment, although maximum benefit may not be achieved for 1 week or longer after starting treatment.
What are the side effects of Wixela?
Common side effects may include headache, muscle pain, bone pain, back pain, nausea, vomiting, thrush, throat irritation, ongoing cough, hoarseness or deepened voice, cold symptoms such as stuffy nose, sneezing, sore throat, or ear infection. More serious side effects can include high blood pressure and osteoporosis.
