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Wixela (Fluticasone / Salmeterol)

Prescription requiredOnly Available By Prescription
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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Wixela is a generic form of the well-known combination inhaler containing fluticasone propionate and salmeterol. This medication is designed to provide significant relief from respiratory conditions such as asthma and COPD. Wixela comes in a specially designed inhaler, which helps patients to administer the medication directly to the lungs for effective symptom management. This inhaler is available in different strengths to accommodate varying medical needs and dosing requirements. Each strength provides a measured dose of fluticasone propionate, a corticosteroid that reduces inflammation, and salmeterol, a long-acting beta-agonist that relaxes muscles in the airways to improve breathing.

Before you buy Wixela inhaler, it is crucial that you talk to your healthcare provider about potential side effects and Wixela inhaler price.

Fact Table
Formula C27H44F2O5 (Fluticasone) / C25H37NO4 (Salmeterol)
License FDA approved
Bioavailability Low for oral administration (first-pass metabolism), higher with inhalation
Legal status Prescription Drugs
Chemical Name Fluticasone propionate / Salmeterol xinafoate
Elimination half-life Fluticasone: ~7.8 hours / Salmeterol: ~5.5 hours
Dosage (Strength) 100/50 µg, 250/50 µg, or 500/50 µg per inhalation (Fluticasone/Salmeterol)
Pregnancy Use with caution; benefits should outweigh risks
Brands Wixela Inhub, Advair Diskus
Protein binding Fluticasone: ~91% / Salmeterol: ~96%
PubChem CID 5311101 (Fluticasone) / 6918314 (Salmeterol)
MedlinePlus a699063 (Advair Diskus)
ChEBI 47974 (Fluticasone propionate) / 50504 (Salmeterol xinafoate)
ATC code R03AK06
DrugBank DB00588 (Fluticasone) / DB00938 (Salmeterol)
KEGG D07937 (Fluticasone) / D02165 (Salmeterol)
Routes of administration Inhalation

Buy Wixela (Fluticasone / Salmeterol) online from online Canadian Pharmacy |


To ensure optimal effectiveness and safety, it is crucial to use Wixela inhaler dose exactly as prescribed by your healthcare provider. It is important not to exceed the prescribed dose. Regular use at the same time each day enhances the effectiveness of the medication.


The active ingredients in Wixela are Fluticasone Propionate and Salmeterol Xinafoate.


Severe cardiovascular disorders, heart rhythm abnormalities, or who are sensitive to beta-adrenergic agonists.

Conditions that could be exacerbated by hypokalemia or hyperglycemia.

A known immune system compromise, as immunosuppressive effects are a risk with any steroid medication.

It is also not recommended for the primary treatment of acute asthma episodes or acute bronchospasms.


Wixela can potentially interact with several other medications, which may enhance or diminish its effects like beta-blockers, diuretics and xanthine derivatives and MAO inhibitors and tricyclic antidepressants. Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs and herbal supplements.

Side Effects

While Wixela is effective in controlling asthma and COPD, it can cause side effects in some patients. Common side effects include:

  • Headache
  • Throat irritation
  • Hoarseness
  • Candidiasis of the mouth and throat (thrush)
  • Musculoskeletal pain
  • Increased heart rate
  • Tremors

Frequently Asked Questions about Wixela (Fluticasone Propionate and Salmeterol)

What is Wixela?

Wixela is a prescription medication that belongs to a class of drugs called combination inhaled corticosteroids and long-acting beta agonists (LABA). It contains two active ingredients, fluticasone propionate and salmeterol.

What is Wixela used for?

Wixela is used to manage the symptoms of asthma and chronic obstructive pulmonary disease (COPD). It helps reduce airway inflammation and improve lung function.

How to use Wixela inhaler?

Wixela is inhaled by mouth twice daily. It’s important to not exhale into the device, and to rinse your mouth with water after each use.

How does Wixela work?

Wixela works by reducing airway inflammation and improving lung function. Fluticasone propionate reduces inflammation in the airways, while salmeterol relaxes the muscles around the airways, allowing them to open up and improve airflow.

Is Wixela a steroid?

Yes, one of the active ingredients in Wixela, fluticasone propionate, is a steroid that lowers inflammation in the lungs.

Does Wixela cause weight gain?

Yes, Wixela may cause some weight gain.

How long does Wixela stay in your system?

The inhaler should be discarded when the dose counter reaches “0,” 1 month after opening the foil pouch, or after the expiration date, whichever comes first.

Does Wixela raise blood pressure?

Wixela may increase your blood pressure. It’s recommended to monitor your blood pressure and speak to your doctor if your blood pressure is high.

How long does Wixela take to work?

Improvement in asthma control following inhaled administration of Wixela can occur within 30 minutes of beginning treatment, although maximum benefit may not be achieved for 1 week or longer after starting treatment.

What are the side effects of Wixela?

Common side effects may include headache, muscle pain, bone pain, back pain, nausea, vomiting, thrush, throat irritation, ongoing cough, hoarseness or deepened voice, cold symptoms such as stuffy nose, sneezing, sore throat, or ear infection. More serious side effects can include high blood pressure and osteoporosis.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.