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Xeljanz (Tofacitinib)

Prescription requiredOnly Available By Prescription
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What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Xeljanz is an anti-inflammatory medication available by prescription and used for treatment of different conditions caused by inflammation. These include rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis among others. Tofacitinib works by disrupting JAK (Janus Kinus) pathways in cells to reduce the body’s inflammatory response. It is often prescribed for those who have not had success with methotrexate or other arthritis medications. Buy Xeljanz from Canada and Canada and get the lowest Xeljanz cost on it.

Fact Table
Formula C16H20N6O
License FDA approved in 2012
Bioavailability 74%
Legal status Prescription only
Chemical Name Tofacitinib
Elimination half-life 3 hours
Dosage (Strength) 5 mg and 10 mg tablets
Pregnancy Use only if clearly needed and the benefit outweighs the risk
Brands Xeljanz, Xeljanz XR
Protein binding 40%
PubChem CID 9926791
MedlinePlus a613042
ATC code L04AA29
DrugBank DB08895
KEGG D09966
Routes of administration Oral

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Standard Xeljanz dosage guidelines are as follows:

Psoriatic arthritis / rheumatoid arthritis - either 5mg orally twice a day (immediate release) or 11mg orally once a day (extended release)

Ulcerative colitis: therapeutic dose of 10 mg orally 2 times a day for initial 8 weeks; Maintenance dose: 5 mg orally 2 times a day


The active ingredient in Xeljanz is Tofacitinib.


Let your doctor know any history of liver or kidney disease or renal failure, tuberculosis, heart problems, lung disease, blood clots, chronic infections, HIV, ulcers, diverticulitis, or diabetes before starting on Xeljanz

It may be necessary to postpone or temporarily discontinue use of Xeljanz XR if you are planning to take a vaccine. Discuss with your doctor before discontinuing use.

Do not take Xeljanz XR is you are pregnant or planning to become pregnant unless your doctor approves it


Negative drug interactions may occur between Xeljanz and other Rx medications, including amlodipine, atorvastatin, duloxetine, gabapentin, hydroxychloroquine, levothyroxine, lisinopril, losartan, pregabalin, meloxicam, methotrexate, omeprazole, pantoprazole, hydroxychloroquine, prednisone, tramadol, and trazodone. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Xeljanz online.

Side Effects

Xeljanz side effects may occur, and some people may experience diarrhea, headache, upper respiratory infections like the common cold, rash, or elevated blood cholesterol levels. If side effects are experienced it may be best to stop use and meet with a doctor again to discuss prescription anti-inflammatory medication alternatives.

Remember, these are not exhaustive lists, and it's important to consult with a healthcare professional for personalized advice and guidance. If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. Visit or call 1-800-FDA-1088

Frequently Asked Questions about Xeljanz

Is Xeljanz a biologic?

No, Xeljanz is not a biologic medication.

Does Xeljanz cause weight gain?

Weight gain is not among the common side effects from using this medication. If you are gaining weight at the same time as you are using Xeljanz then the weight gain is not likely due to the medication.

Is Xeljanz an immunosuppressant?

No, Xeljanz is not an immunosuppressant. It is a JAK (Janus Kinase) inhibitor class medication.

Do Xeljanz side effects go away?

For most users, the side effects from using this medication are temporary, but some people may be more likely to have them last longer based on their physiology or overall health. If side effects continue and are unbearable, you may want to stop using Xeljanz and discuss this with your doctor.

Does Xeljanz cause hair loss?

Hair loss is not among the common side effects from using this medication. If you are losing hair at the same time as you are using Xeljanz, then the hair loss is not likely due to the medication.

How long does it take Xeljanz to work?

Most users will experience relief from inflammation pain and/or immobility within 3-6 hours of taking a dose of this medication.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.