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Xifaxan (Rifaximin)

Also Known as Zaxine,Coldir

Prescription requiredOnly Available By Prescription
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What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Xifaxan is a prescription traveler's diarrhea treatment medication that may also be prescribed to treat IBS with diarrhea. Rifaximin is an antibiotic that works by killing the bacteria that are causing diarrhea and additional gastrointestinal upset when introduced to the stomach, as occurs with traveler's diarrhea. With IBS, it works to address imbalances in gut bacteria that arise over time and contribute to that part of the condition. Xifaxan may also be prescribed to treat hepatic encephalopathy when a person has liver problems and an overgrowth of bacteria in the organ.

You can buy Xifaxan with a prescription, and your lowest Xifaxan cost will be when you order medication online from Canada and Canpharm.

What is Travelers Diarrhea?

Traveler's diarrhea is a common problem that can happen when you travel to different places, especially in countries that are still developing. It's when you get diarrhea, which means having loose and watery poop, while on your trip or shortly after. This usually occurs because you drink water with germs or eat food infected with bacteria, viruses, or parasites. Your body isn't used to those specific germs, so it can make you sick. To avoid getting traveler's diarrhea, you must be careful about what you eat and drink while traveling. Stick to drinking bottled water and avoid eating raw fruits and veggies that haven't been peeled or cooked. Taking these precautions can lower the risk of getting a traveler's diarrhea and stay healthy while traveling.

Fact Table
Formula C43H51N3O11
License US FDA
Bioavailability Less than 4%
Legal status Rx-Only
Chemical Name Rifaximin
Elimination half-life 6 hours
Dosage (Strength) 200mg, 550mg
Pregnancy Not Recommended
Brands Xifaxan
Protein binding 67.5%
PubChem CID 6436173
MedlinePlus a604027
ChEBI 75246
ATC code A07AA11
DrugBank DB01220
KEGG D02554
Routes of administration By mouth (tablets)

Buy Xifaxan (Rifaximin) online from online Canadian Pharmacy |


Traveler's diarrhea: Take 1 Xifaxan 550mg tablet thrice daily at 8-hour intervals as needed.

IBS with diarrhea: Take 1 Xifaxan 500mg tablet three times daily at 8-hour intervals for 14 days (2 weeks) before assessing the effectiveness and readjusting dosage or frequency based on your doctor's determination.

Medication can be taken with or without food.


The active ingredient in Xifaxan is Rifaximin.


Let your doctor know of any history of liver disease or diverticulitis before starting on Xifaxan.

Medication is for use with ages 12 and up only.

Xifaxan may reduce the effectiveness of live vaccines or immunizations and either may need to be postponed until medication use is complete.

Keep medication in cool and dry place.

Be aware of medication expiry date.


Negative drug interactions may occur between Xifaxan and other Rx or OTC medications, including dicyclomine, folic acid, furosemide, gabapentin, hydroxyzine, lactulose, levothyroxine, lisinopril, magnesium oxide, metformin, omeprazole, oxycodone, pantoprazole, prednisone, propranolol, spironolactone, tramadol, trazodone, cyanocobalamin, cholecalciferol.

Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Xifaxan online.

Side Effects

Xifaxan side effects may occur, and some users may experience abdominal or stomach pain, cramping, blood or mucus in stool, rash, itching or swelling of face, tongue, or throat, dizziness, or breathing difficulties. If Xifaxan side effects are seen you may want to discontinue use and meet with your doctor again to discuss traveler’s diarrhea treatment medication alternatives.

Frequently Asked Questions about Xifaxan

What is Xifaxan Used for?

Xifaxan (rifaximin) is a medication used to treat certain gastrointestinal conditions. It is primarily prescribed for treating traveler's diarrhea caused by E. coli bacteria and for managing irritable bowel syndrome with diarrhea (IBS-D) in adults.

Is Xifaxan an Antibiotic?

Yes, Xifaxan is an antibiotic. It treats certain gastrointestinal conditions and belongs to a class of antibiotics called rifamycins.

How Long Does Xifaxan Stay in Your System?

Xifaxan has an elimination half-life of approximately 6 hours. On average, it takes about five half-lives for a medication to be eliminated from the body. Therefore, Xifaxan is estimated to stay in the system for around 30 hours after the last dose.

Why is Xifaxan so Expensive?

The cost of Xifaxan can be relatively high for several reasons, like research and development costs, manufacturing expenses, insurance coverage, and specific healthcare systems. If you want to buy Xifaxan online, you can get the best price on Canpharm. By choosing Xifaxan generic available on Canpharm, you can also achieve substantial cost savings.

Does Alcohol Interact with Xifaxan?

There are no known significant interactions between alcohol and Xifaxan. However, it is generally recommended to avoid excessive alcohol consumption, as it can potentially worsen gastrointestinal symptoms and counteract the intended effects of the medication. It is advisable to consult with a healthcare professional for personalized advice regarding alcohol consumption while taking Xifaxan.

How Long Do Xifaxan Side Effects Last?

Common Xifaxan side effects may include bloating, gas, stomach pain, nausea, and headache. Typically, these side effects are mild and temporary, lasting for a few days up to a few weeks. However, if they become more severe / don't go away, talk to your doctor.

Should I Take a Probiotic While Taking Xifaxan?

Taking a probiotic while on Xifaxan is a topic that may vary depending on individual circumstances and healthcare provider recommendations. Probiotics are beneficial bacteria that can help restore and maintain a healthy balance in the gut. Some healthcare providers may suggest taking a probiotic alongside Xifaxan to support gut health.

How Long Does Xifaxan Take to Work?

The onset of action for Xifaxan can vary depending on the treated condition. For traveler's diarrhea, relief of symptoms is often observed within 24 to 48 hours of starting treatment. In the case of irritable bowel syndrome with diarrhea (IBS-D), it may take a few weeks of consistent use to experience the full benefits of Xifaxan.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.