Xigduo (Dapagliflozin / Metformin)
| Dose | Size & Price | Qty |
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Description
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Fact Table
| Fact Table | |
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| Formula | Dapagliflozin: C21H25ClO6 Metformin: C4H11N5 |
| License | FDA approved |
| Bioavailability | Dapagliflozin: 78% (oral) Metformin: 50–60% (oral) |
| Legal status | Prescription Drug |
| Chemical Name | Dapagliflozin: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol Metformin: 3-(diaminomethylidene)-1,1-dimethylguanidine |
| Elimination half-life | Dapagliflozin: ~12.9 hours Metformin: ~6.2 hours |
| Dosage (Strength) | Combination strengths (Dapagliflozin/Metformin): 5mg/500mg, 5mg/1000mg, 10mg/500mg, 10mg/1000mg tablets |
| Pregnancy | Use with caution; consult doctor |
| Brands | Xigduo XR |
| Protein binding | Dapagliflozin: ~91% Metformin: Negligible |
| PubChem CID | Dapagliflozin: 9887712 Metformin: 4091 |
| MedlinePlus | a614043 |
| ChEBI | Dapagliflozin: 6857918 Metformin: 6801 |
| ATC code | A10BD15 |
| DrugBank | Dapagliflozin: DB06292 Metformin: DB00331 |
| KEGG | Dapagliflozin: D08907 Metformin: D04966 |
| Routes of administration | By mouth |
Xigduo is a combination Type 2 diabetes treatment medication used to lower blood sugar levels for people, and it may also be prescribed for people with chronic kidney disease or worsening heart failure risk. Dapagliflozin is a sodium-glucose cotransporter inhibitor drug that prevents glucose absorption and Metformin is a biguanides derivative that will also limit glucose production in the liver plus improve insulin sensitivity. You can buy Xigduo with a prescription from Canpharm.
Directions
Standard dosage for Xigduo medication is to take one of the 2.5mg / 5mg / 10mg tablets 1x daily, and dosage strength will vary between patients. Always take medication at the dosage strength and frequency indicated in your prescription, and it is best to take it in the morning and with food if you experience stomach upset.
Ingredients
The active ingredients in Xigduo are Dapagliflozin and Metformin
Cautions
Let your doctor know of any history of liver or kidney disease, diabetic ketoacidosis, or polycystic kidney disease before starting on Xigduo
Use of this medication may increase the risk of bone fractures
Xigduo can cause ovulation for women outside of regular menstrual cycles and increase the chance of becoming pregnant
Older adults may be more susceptible to side effects from this medication
Use of Xigduo may affect the accuracy of certain lab tests
Interactions
Negative drug interactions may occur between Xigduo and other Rx or OTC medications, including amlodipine, furosemide, hydrochlorothiazide, levothyroxine, lisinopril, losartan, meloxicam, metformin, metoprolol, tamsulosin, and insulin degludec (Tresiba). Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Xigduo online.
Side Effects
Xigduo side effects may occur, and some users may experience diarrhea, headache, kidney or bladder infections, common cold symptoms, or yeast infections. If side effects are seen you may want to discontinue use and meet with a doctor again to discuss Type 2 diabetes treatment medications and a pharmacist for a lower Xigduo price.
Frequently Asked Questions about Xigduo XR (Dapagliflozin and Metformin)
What is Xigduo?
Xigduo XR is a prescription medication used to manage type 2 diabetes. It is a combination of two active ingredients: dapagliflozin (a sodium-glucose co-transporter 2 (SGLT2) inhibitor) and metformin (a biguanide). Together, these help lower blood sugar levels in adults with type 2 diabetes.
Can I take Xigduo at night?
Yes, Xigduo XR is typically taken once daily with food, preferably in the morning to reduce the risk of stomach upset. However, if your doctor prescribes it differently, follow their instructions.
How long does it take for Xigduo to start working?
Xigduo starts lowering blood sugar within a few hours of taking it, but full effects may take several days to weeks to be noticeable, depending on individual response and overall diabetes management.
What is Xigduo used for?
Xigduo XR is used to lower blood sugar levels in adults with type 2 diabetes. It may also provide additional benefits, such as weight loss and improved cardiovascular health.
Can you take Xigduo twice a day?
Xigduo XR is an extended-release (XR) formulation that is designed to be taken once daily. Taking it twice a day is not recommended unless instructed by your doctor.
Does Xigduo cause diarrhea?
Yes, diarrhea is a possible side effect, mainly due to the metformin component in Xigduo XR. This side effect is usually temporary but can be reduced by taking the medication with food.
How does Xigduo work?
Xigduo works by:
- Dapagliflozin (SGLT2 Inhibitor) – Helps the kidneys remove excess sugar through urine.
- Metformin (Biguanide) – Lowers glucose production in the liver and improves insulin sensitivity.
Together, these help control blood sugar and may provide additional health benefits.
How long does Xigduo stay in your system?
Dapagliflozin has a half-life of about 12–13 hours and is mostly cleared within 2–3 days.
Metformin has a half-life of about 4–9 hours and is cleared within 1–2 days.
The effects, however, continue as long as you take the medication consistently.
Is Xigduo safe?
Xigduo XR is FDA-approved and considered safe when taken as prescribed. However, it may cause side effects such as:
- Dehydration and dizziness (due to increased urination)
- Diarrhea or stomach upset
- Low blood sugar (hypoglycemia) (when combined with other diabetes medications)
- Urinary tract infections (UTIs)
Consult your doctor if you have kidney disease, heart failure, or other health conditions before taking Xigduo.
Can Xigduo cause weight loss?
Yes, Xigduo may help with weight loss, mainly due to dapagliflozin’s ability to remove excess glucose through urine, which can result in calorie loss. However, the weight loss is usually moderate and varies from person to person.
