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Only Available By Prescription
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Zenpep is a prescription pancreatic enzyme replacement therapy (PERT) designed to aid in the digestion of fats, proteins, and carbohydrates in individuals with exocrine pancreatic insufficiency (EPI), commonly associated with conditions like cystic fibrosis and chronic pancreatitis. Each Zenpep 40,000 capsule contains a precise blend of lipase, protease, and amylase enzymes to support optimal nutrient absorption and digestive function. For patients seeking effective enzyme support, buy Zenpep as part of a comprehensive management plan for EPI.
| Fact Table | |
|---|---|
| Formula | Not applicable (mixture of enzymes: lipase, protease, amylase) |
| License | FDA approved |
| Bioavailability | Not systemically absorbed (acts locally in the GI tract) |
| Legal status | Prescription only |
| Chemical Name | Pancrelipase (porcine-derived lipase, protease, amylase) |
| Elimination half-life | Not applicable (not absorbed) |
| Dosage (Strength) | Varies: Lipase 3,000–40,000 USP units per capsule |
| Pregnancy | Use only if clearly needed; animal data show low risk |
| Brands | Zenpep |
| Protein binding | Not applicable |
| PubChem CID | Not available (mixture of enzymes) |
| MedlinePlus | a604035 |
| ChEBI | 9516 (for lipase) |
| ATC code | A09AA02 |
| DrugBank | DB00085 |
| KEGG | D02175 |
| Routes of administration | Oral (delayed-release capsules) |
Zenpep should be taken exactly as prescribed by a healthcare provider. Capsules should be swallowed whole with sufficient fluid during meals or snacks. Do not crush or chew the capsules or their contents to avoid irritation of the oral mucosa. Dosage is individualized based on the severity of enzyme insufficiency, dietary fat intake, and weight. Patients are encouraged to discuss any adjustments or missed doses with their clinician.
Zenpep contains a combination of porcine-derived pancreatic enzymes:
Other ingredients include hypromellose, triethyl citrate, sodium lauryl sulfate, and various capsule excipients. The enteric-coated microspheres ensure enzyme activity is preserved until reaching the small intestine.
Long-term use of Zenpep at high doses may increase the risk of fibrosing colonopathy, particularly in pediatric patients with cystic fibrosis. Careful monitoring is advised, especially when high enzyme doses are required. To manage Zenpep cost, patients may explore copay assistance programs or speak with their pharmacist about financial support options. Avoid inhaling enzyme powder or allowing prolonged skin contact, as it may cause irritation or allergic reactions.
Zenpep is contraindicated in patients with known hypersensitivity to porcine proteins or any component of the formulation. It should not be used during episodes of acute pancreatitis or in the acute exacerbation of chronic pancreatitis unless deemed necessary by a healthcare provider.
Common and serious side effects associated with Zenpep include:
Seek immediate medical attention if any signs of a severe allergic reaction occur.
What is ZenPep?
ZenPep is a prescription pancreatic enzyme replacement therapy (PERT) that contains a mixture of digestive enzymes (lipases, proteases, and amylases) naturally produced by the pancreas. It helps your body digest fats, proteins, and carbohydrates in the foods you eat.
What conditions is ZenPep used to treat?
ZenPep is prescribed to treat exocrine pancreatic insufficiency (EPI) due to conditions such as cystic fibrosis, chronic pancreatitis, pancreatectomy, pancreatic cancer, or other conditions that affect pancreatic function.
How does ZenPep work?
ZenPep replaces the digestive enzymes your pancreas would normally produce. These enzymes help break down fats, proteins, and carbohydrates in your food, allowing your body to absorb the nutrients properly.
How should I take ZenPep?
Take ZenPep exactly as prescribed by your healthcare provider. It should be taken with every meal and snack, usually just before or during eating. Capsules should be swallowed whole with plenty of water.
Can ZenPep capsules be opened?
For patients who have difficulty swallowing capsules, ZenPep capsules can be opened and the contents sprinkled on soft, acidic foods like applesauce. Do not crush or chew the contents.
What if I miss a dose?
If you miss a dose, take it as soon as you remember if you are still eating or have just finished a meal. If it's almost time for your next dose, skip the missed dose. Do not take double doses.
How do I store ZenPep?
Store ZenPep at room temperature (between 59°F to 86°F or 15°C to 30°C). Keep the bottle tightly closed and protect from moisture.
What are the common side effects of ZenPep?
Common side effects may include abdominal pain, gas, headache, dizziness, bloating, nausea, diarrhea, or constipation.
What serious side effects should I watch for?
Serious side effects include severe abdominal pain, joint pain, or allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing). Contact your doctor immediately if you experience any of these.
Can ZenPep cause fibrosing colonopathy?
High doses of pancreatic enzyme products have been associated with a rare bowel condition called fibrosing colonopathy, especially in children with cystic fibrosis. Follow your doctor's dosing instructions carefully.
Who should not take ZenPep?
ZenPep should not be taken by people with a known allergy to pork proteins or any of the ingredients in ZenPep. Make sure to tell your doctor about all allergies.
Does ZenPep interact with other medications?
ZenPep may interact with certain medications, including antacids containing calcium carbonate or magnesium hydroxide. Tell your healthcare provider about all medications, supplements, and herbal products you take.
Can I take ZenPep with acid-reducing medications?
Yes, but be aware that acid-reducing medications (like PPIs or H2 blockers) might affect how ZenPep works. Discuss with your doctor if you're taking these medications.
Do I need to change my diet while taking ZenPep?
Follow any dietary recommendations from your healthcare provider. Generally, a balanced diet is recommended, though some people with EPI may benefit from specific dietary adjustments.
Can I drink alcohol while taking ZenPep?
Alcohol can irritate the pancreas. Consult with your healthcare provider about alcohol consumption while taking ZenPep.
Is ZenPep safe during pregnancy or breastfeeding?
Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Limited data exists on ZenPep use during pregnancy and breastfeeding.
Is ZenPep appropriate for children?
ZenPep is approved for use in children, but dosage is typically adjusted based on age, weight, and condition. Always follow your pediatrician's guidance.
