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Zepbound (tirzepatide)

Prescription requiredOnly Available By Prescription
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Zepbound is an injectable medication that, along with a reduced-calorie diet and increased physical activity, is used for chronic weight management in obese or overweight adults who have one or more weight-related comorbid conditions, such as high blood pressure, dyslipidemia, type 2 diabetes, obstructive sleep apnea, or cardiovascular disease. Zepbound is available by prescription only.

Zepbound is supplied as single-dose injectable pens. The pens are available in 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL.

Fact Table
Formula C225H348N48O68
License US DailyMed
Bioavailability 80%
Legal status Rx-Only
Chemical Name Tirzepatide
Elimination half-life Five days
Dosage (Strength) 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL
Pregnancy Consult Doctor
Brands Zepbound
Protein binding 99%
PubChem CID 156588324
MedlinePlus a622044
ChEBI 194186
ATC code A10BX16
DrugBank DB15171
KEGG D11360
Routes of administration Subcutaneous

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Zepbound should be used as directed by your doctor. Inform your doctor or pharmacist of any questions or concerns you may have about the medication.

Your healthcare provider will determine an appropriate dose for you and will instruct you on the proper administration of Zepbound. Inject your prescribed dose once weekly underneath the skin in the abdomen, thigh, or upper arm. Be sure to rotate your injection sites with each dose.


Store Zepbound in the refrigerator between 2°C and 8°C (36°F and 46°F) in its original carton. Avoid freezing the medication.

You may store the pens at 30°C (86°F) or below for up to 21 days. If you choose to store them at room temperature, do not place them back into the refrigerator. Properly dispose of the medication if it has not been used within 21 days of taking it out of the refrigerator.

Keep all medications away from children’s reach.


The ingredient in the type 2 diabetes medication Mounjaro®, tirzepatide, is the active ingredient in Zepbound.


Patients with a personal or family history of medullary thyroid carcinoma or patients with Multiple Endocrine Neoplasia syndrome type 2 should avoid using Zepbound.

Patients who are allergic to tirzepatide or to any of the excipients in Zepbound should also avoid using the medication.


Zepbound contains the following FDA Boxed Warning:

  • Thyroid C-cell tumors in rats have been shown to be caused by tirzepatide. It is not known whether Zepbound causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans.
  • Zepbound should not be used in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Patients should be educated on the potential risk of MTC and symptoms of thyroid tumors.
  • Before you are started on Zepbound, inform your doctor of:
    • All the medications you take, including prescription and nonprescription medications
    • Your allergies
    • Your active health problems and past medical history
    • Whether you are pregnant or breastfeeding
  • Using Zepbound can cause:
    • Gastrointestinal adverse reactions that can potentially be severe. Zepbound has not been studied in patients with severe gastrointestinal disease and is not recommended for use in these patients.
    • Acute kidney injury
    • Acute gallbladder disease
    • Acute pancreatitis
    • Hypersensitivity reactions, including anaphylaxis and angioedema (swelling). Emergency care should be immediately sought if a patient develops signs or symptoms of an allergic reaction.
    • Low blood sugar if using Zepbound with insulin products. A dose adjustment may be needed. Patients should be educated on the signs and symptoms of low blood sugar levels and how to properly treat an occurrence of low blood sugar.
    • Diabetic retinopathy complications in patients with type 2 diabetes.
    • Suicidal behavior and ideation. Zepbound should be discontinued if patients develop these symptoms.
    • Fetal harm. Females who are on oral contraceptives are advised to switch to non-oral contraceptives or add a barrier contraceptive method for 4 weeks after Zepbound initiation and for 4 weeks after each dose increase.

Side Effects

Common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, injection site reactions, fatigue, hypersensitivity reactions, eructation, hair loss, and gastroesophageal reflux disease. Other side effects can also occur, so be sure to inform your doctor of any worrisome or persistent side effects.

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  1. Zepbound. Indianapolis, IN: Lilly USA, LLC; 2023.

Frequently Asked Questions about Zepbound (Tirzepatide)

What is Zepbound?

Zepbound is a prescription medication used to treat type 2 diabetes in adults. Tirzepatide is a dual-agonist of the GLP-1 and GIP receptors.

How does Zepbound work?

Zepbound works by increasing insulin production and decreasing glucagon production when blood sugar levels are high. It also helps to slow down the emptying of the stomach, which can help to improve blood sugar control.

What are the benefits of taking Zepbound?

Zepbound can be an effective way to lower blood sugar levels in people with type 2 diabetes. It can also help to improve other health markers, such as weight loss and blood pressure.

What are the side effects of taking Zepbound?

The most common side effects of taking Zepbound are nausea, vomiting, diarrhea, and abdominal pain. These side effects are usually mild and go away on their own. Other possible side effects include low blood sugar, pancreatitis, and allergic reactions.

Who should not take Zepbound?

Zepbound is not recommended for people with type 1 diabetes, diabetic ketoacidosis, or a history of pancreatitis. It is also not recommended for people who are pregnant or breastfeeding.

How is Zepbound administered?

Zepbound is administered by injection under the skin once a week. The injection can be given at any time of day, with or without food.

What happens if I miss a dose of Zepbound?

If you miss a dose of Zepbound, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once.

Can I take Zepbound with other medications?

Zepbound can interact with other medications, including insulin, sulfonylureas, and meglitinides. It is important to talk to your doctor about all of the medications you are taking before starting Zepbound.

What are the storage requirements for Zepbound?

Zepbound should be stored in the refrigerator between 36°F and 46°F (2°C and 8°C). Do not freeze Zepbound.

What is the cost of Zepbound?

The cost of Zepbound will vary depending on your insurance coverage. However, Zepbound is available through most major insurance plans.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.