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Fact Table
| Fact Table | |
|---|---|
| Formula | C9H13N5O4 |
| License | FDA approved (2009) |
| Bioavailability | Minimal systemic absorption (topical ophthalmic use) |
| Legal status | Prescription only (Rx) |
| Chemical Name | 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine |
| Elimination half-life | ~3–4 hours (systemic; negligible after ophthalmic use) |
| Dosage (Strength) | 0.15% ophthalmic gel; apply 1 drop 5× daily until healing, then 1 drop 3× daily for 7 days |
| Pregnancy | Category C – Use only if potential benefit justifies risk |
| Brands | Zirgan |
| Protein binding | ~1–2% |
| PubChem CID | 3454 |
| MedlinePlus | a600019 |
| ChEBI | 3467 |
| ATC code | S01AD09 |
| DrugBank | DB01004 |
| KEGG | D00290 |
| Routes of administration | Ophthalmic (eye gel) |
Zirgan (ganciclovir) is an antiviral medication used to treat acute herpetic keratitis, which are eye ulcers caused by the herpes simplex virus. This topical ophthalmic gel helps heal corneal ulcers by stopping the virus from making more copies of itself. The gel is placed directly in the affected eye and mainly works on infected cells to help clear the infection without harming healthy eye tissue.
Directions
Zirgan is applied directly to the affected eye as a topical ophthalmic gel. The standard dosage is one drop into the affected eye five times per day, roughly every three hours while awake, until the corneal ulcer heals. After the ulcer heals, the dosage is one drop three times daily for seven days.
Ingredients
The active ingredient in Zirgan is ganciclovir.
Cautions
- Before using this medication, you may want to consult a healthcare provider about the following:
- Any existing health conditions
- Any allergies
- A list of all medications currently being taken
- Zirgan is for use in the eye only and should not be applied to the skin or taken by mouth.
- Contact lenses should not be worn if you have symptoms of herpetic keratitis or while you are using Zirgan, as lenses can worsen irritation and interfere with healing.
Contraindications
There are no listed contraindications on the drug label. However, avoid taking or using this medication if you have a known hypersensitivity to ganciclovir.
Side Effects
Common side effects of Zirgan include:
- Blurred vision
- Eye irritation
- Redness of the eye
- Punctate keratitis
These effects are usually limited to the treated eye and may often occur shortly after applying the gel. Blurred vision is the most commonly reported reaction but is usually mild and temporary. Mild eye irritation or redness may also occur after applying it to the eye.
More serious side effects are uncommon but may include worsening eye pain, increased redness, or persistent changes in vision. Contact a healthcare provider if eye discomfort does not improve, vision changes continue, or symptoms of infection develop.
Frequently Asked Questions about Zirgan Eye Gel
What is Zirgan Eye Gel used for?
Zirgan Eye Gel is an antiviral ophthalmic medication used to treat acute herpetic keratitis, an eye infection caused by the herpes simplex virus. It helps stop the virus from multiplying in the eye, allowing the infection to heal.
How does Zirgan Eye Gel work?
Zirgan contains ganciclovir, which interferes with viral DNA replication. By preventing the virus from reproducing, it limits the spread of infection within the cornea.
How is Zirgan Eye Gel typically used?
The gel is applied directly into the affected eye as prescribed, usually several times a day during the initial phase, then less often as the eye begins to heal. Hands should be washed before and after application.
How long does it take for Zirgan to work?
Many people begin to notice improvement in symptoms within a few days, but treatment is usually continued for the full prescribed duration to ensure complete resolution of the infection.
What are the common side effects of Zirgan Eye Gel?
Common side effects include blurred vision immediately after application, mild eye irritation, redness, or a temporary burning or stinging sensation. These effects are usually short-lived.
Can Zirgan Eye Gel affect vision?
Temporary blurred vision may occur right after applying the gel. This usually clears quickly, but activities requiring clear vision should be avoided until vision returns to normal.
Is Zirgan safe to use with contact lenses?
Contact lenses should generally not be worn during treatment for an active eye infection. If lenses are used, they should be removed before applying the gel and only reinserted if advised by a healthcare professional.
Can Zirgan Eye Gel be used in both eyes?
Zirgan is typically used only in the affected eye unless both eyes are infected. Using it unnecessarily in an uninfected eye is not recommended.
Is Zirgan Eye Gel safe during pregnancy or breastfeeding?
Systemic absorption from eye use is very low, but safety during pregnancy or breastfeeding should be carefully considered. Use is generally based on whether the potential benefit outweighs any possible risk.
Does Zirgan cure herpes eye infections permanently?
Zirgan treats the active infection but does not eliminate the herpes virus from the body. Recurrences can happen, and future episodes may require additional treatment.
