| Fact Table | |
|---|---|
| Formula | C12H11ClN2O5S |
| License | FDA approved (1966); EMA approved |
| Bioavailability | ~47–64% (oral; variable) |
| Legal status | Prescription only (Rx) |
| Chemical Name | 4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid |
| Elimination half-life | ~1.5–2 hours (prolonged in renal impairment) |
| Dosage (Strength) | Tablets: 20 mg, 40 mg, 80 mg; Oral solution: 10 mg/mL; Injection: 10 mg/mL |
| Pregnancy | Category C – Use only if potential benefit justifies potential risk |
| Brands | Lasix (Sanofi), generics widely available |
| Protein binding | ~95% |
| PubChem CID | 3440 |
| MedlinePlus | a682858 |
| ChEBI | 4751 |
| ATC code | C03CA01 |
| DrugBank | DB00695 |
| KEGG | D00359 |
| Routes of administration | By mouth (oral); intravenous; intramuscular |
Lasix (furosemide) is a loop diuretic, or water pill, used to reduce fluid buildup and lower blood pressure. It helps the kidneys remove extra water and salt through the urine. Doctors or healthcare providers typically prescribe it for swelling caused by heart failure, liver disease, or kidney disease. It’s also sometimes used to treat high blood pressure, either alone or with other medications.
Furosemide is usually taken by mouth at the same time each day as directed by a healthcare provider. For adults with edema, the typical starting dose ranges from 20 to 80 mg per day as a single dose. The dosage may be adjusted based on treatment response, with increases of 20 to 40 mg occurring no sooner than 6 to 8 hours after the previous dose.
If taken once daily, it's recommended to take furosemide in the morning after breakfast. When prescribed more than once per day, the last dose should be taken at least 6 hours before bedtime to reduce the urge to urinate at nighttime. For hypertension, the usual initial dose is 40 mg twice daily, although the dosage may be changed as necessary.
The active ingredient in Lasix is furosemide.
Before using this medication, you may want to consult a healthcare provider about the following:
Lasix can cause changes in fluid and electrolytes, especially at higher doses. It’s important to monitor for dehydration, low blood pressure, dizziness, weakness, or heart rhythm problems.
People with liver disease, particularly cirrhosis with fluid buildup in the abdomen, may need to start Lasix in the hospital. Sudden changes in fluids or salts may worsen liver function and, in severe cases, trigger liver-related confusion or coma.
Lasix can worsen kidney function in some people. If urine output drops or kidney lab tests get worse, the medication may need to be stopped.
Hearing problems, including ringing in the ears or temporary or permanent hearing loss, have been reported, especially with high doses, rapid IV use, kidney disease, or when combined with certain antibiotics. Slow, controlled dosing lowers this risk.
Blood sugar levels may increase during treatment, and in rare cases Lasix can unmask or worsen diabetes. People with diabetes should monitor their glucose closely.
Men with prostate problems or anyone with trouble emptying their bladder may develop sudden urinary retention when starting Lasix and should be watched carefully.
Lasix may increase uric acid levels and can occasionally trigger gout attacks, even if symptoms were not present before.
People with low blood protein levels may not respond as well to Lasix and may be at higher risk for side effects, including hearing problems.
Contraindications
Avoid taking or using this medication if any of the following apply:
Common side effects of Lasix include:
These side effects are related to Lasix’s strong diuretic effects and changes in fluid and electrolyte balance. Dizziness can occur, especially when standing up quickly, and may be worse with alcohol use.
More serious side effects can include severe allergic reactions, hearing changes such as ringing in the ears or hearing loss, kidney inflammation, blood disorders, or severe skin reactions like Stevens-Johnson syndrome.
Lasix may also affect blood sugar, uric acid, or cholesterol levels and, in rare cases, cause liver or pancreatic problems. Seek medical help if you develop severe rash, hearing changes, signs of infection or bleeding, confusion, or persistent weakness.
What is Lasix (furosemide) used for?
Lasix is a prescription diuretic used to treat fluid retention caused by conditions such as heart failure, liver disease, and kidney disease, and it is also used to help lower high blood pressure.
How does Lasix work?
Lasix works by helping the kidneys remove excess salt and water from the body through urine, which reduces swelling and decreases fluid buildup.
How quickly does Lasix start working?
Lasix usually begins to work within one hour after an oral dose, with increased urination occurring soon after.
How should Lasix be taken?
Lasix is taken by mouth as directed, with dosing based on the medical condition and response to treatment, and it is often taken earlier in the day to reduce nighttime urination.
What are the most common side effects of Lasix?
Common side effects include increased urination, dehydration, dizziness, low blood pressure, headache, and electrolyte imbalances such as low potassium.
Can Lasix affect potassium levels?
Yes, Lasix can cause the body to lose potassium, which may lead to muscle cramps, weakness, or abnormal heart rhythms if levels become too low.
Who should use caution when taking Lasix?
People with kidney problems, liver disease, gout, diabetes, or electrolyte imbalances should use Lasix with caution.
Can Lasix interact with other medications?
Lasix may interact with blood pressure medications, lithium, NSAIDs, certain antibiotics, and drugs that affect electrolyte levels.
Can Lasix be used long-term?
Lasix can be used long-term when medically necessary, but ongoing monitoring of kidney function, blood pressure, and electrolytes is important.
What should I do if I miss a dose of Lasix?
If a dose is missed, it should be taken as soon as remembered unless it is close to the next dose, in which case the missed dose should be skipped.
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (e.g., different shape or color), as trademark laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.