Synthroid (Levothyroxine)
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Description
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Fact Table
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| Formula | C15H11I4NO4 |
| License | FDA approved |
| Bioavailability | 40–80% (variable; affected by fasting, GI pH, and other factors) |
| Legal status | Prescription Drugs |
| Chemical Name | Levothyroxine sodium |
| Elimination half-life | 6–7 days (euthyroid); 9–10 days (hypothyroid); ~3 days (hyperthyroid) |
| Dosage (Strength) | 25mcg, 50mcg, 75mcg, 88mcg, 100mcg, 112mcg, 125mcg, 137mcg, 150mcg, 175mcg, 200mcg, 300mcg |
| Pregnancy | Safe during pregnancy; dosage adjustment typically required |
| Brands | Synthroid, Eltroxin, Levoxyl, Euthyrox, Thyronorm, others |
| Protein binding | ~99% (primarily to thyroxine-binding globulin, transthyretin, and albumin) |
| PubChem CID | 5819 |
| MedlinePlus | a682461 |
| ChEBI | 42068 |
| ATC code | H03AA01 |
| DrugBank | DB00451 |
| KEGG | D08125 |
| Routes of administration | By mouth, intravenous |
Synthroid is a hypothyroidism treatment medication available by prescription and used to compensate for an underactive thyroid gland and insufficient thyroid hormone production. It may also be prescribed as part of thyroid cancer treatment, but this is not something that will happen often. Levothyroxine is formulated to promote greater hormone production from the thyroid gland so that energy regulation for cells in the body occurs more in the way it should for optimal health and vitality. You can buy Synthroid with a prescription here at Canpharm.
Directions
Standard Synthroid dosage is to take medication 1-2x daily as indicated in your prescription and this medication should be taken on an empty stomach and 30 minutes to 1 hour before breakfast. Capsules should be swallowed whole with a full glass of water.
Ingredients
The active ingredient in Synthroid is Levothyroxine
Cautions
Let your doctor know of any history of adrenal gland dysfunction, heart disease, irregular heartbeat, hypertension (high blood pressure), or diabetes before starting on Synthroid
This medication may increase blood sugar levels for diabetics
Side effects from this medication may be more pronounced for children and older adults
Store at room temperature and away from moisture and heat
Interactions
Negative drug interactions may occur between Synthroid and other Rx or OTC medications, including albuterol, amlodipine, atorvastatin, rosuvastatin, duloxetine, gabapentin, hydrochlorothiazide, furosemide, lisinopril, losartan, metformin, metoprolol, omeprazole, pantoprazole, prednisone, montelukast, sertraline, cetirizine, tramadol, and trazodone. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Synthroid online.
Side Effects
Synthroid side effects may occur, and some users may experience hair loss, heat sensitivity, increased perspiration, diarrhea, headache, shortness of breath, bone pain or fragility, or mental / mood changes. If side effects are seen you may want to discontinue use and meet with a doctor again to discuss hypothyroidism treatment medication alternatives.
Frequently Asked Questions about Synthroid
What is Synthroid used for?
Synthroid is primarily prescribed to treat hypothyroidism, a condition where the thyroid gland does not produce sufficient thyroid hormone. It is also used in certain cases to manage thyroid cancer.
How should I take Synthroid?
Synthroid should be taken orally, typically once daily on an empty stomach, 30 to 60 minutes before breakfast. Consistency in the timing of the dose and relation to meals enhances absorption.
What are the possible side effects of Synthroid?
Common side effects may include increased appetite, weight loss, heat sensitivity, excessive sweating, headache, hyperactivity, nervousness, and anxiety. Overdosage can lead to symptoms of hyperthyroidism.
Can I take Synthroid with other medications?
Certain medications and supplements can interfere with Synthroid's absorption or effectiveness. It's important to inform your healthcare provider about all medications and supplements you're taking.
Is Synthroid safe during pregnancy and breastfeeding?
Yes, maintaining appropriate thyroid hormone levels is crucial during pregnancy and breastfeeding. Your healthcare provider may adjust your dosage during these periods.
How is the correct dosage of Synthroid determined?
The appropriate dosage is individualized based on factors like age, weight, severity of hypothyroidism, and other health conditions. Regular blood tests are conducted to monitor thyroid hormone levels and adjust the dosage accordingly.
What should I do if I miss a dose?
If you miss a dose of Synthroid, take it as soon as you remember. If it's close to the time of your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Are there any dietary restrictions while taking Synthroid?
Certain foods and supplements, such as those high in fiber, soy products, and iron or calcium supplements, can affect Synthroid absorption. It's advisable to maintain a consistent diet and consult your healthcare provider for personalized advice.
Can Synthroid cause bone loss?
Recent studies suggest that long-term use of levothyroxine, especially in older adults, may be associated with increased bone loss, even when thyroid levels are within the normal range. It's important to have regular check-ups with your healthcare provider to monitor bone health.
Is Synthroid the only treatment option for hypothyroidism?
While Synthroid (levothyroxine) is commonly prescribed, other treatment options include natural desiccated thyroid extract and combination therapies. The choice of treatment should be discussed with your healthcare provider based on your specific condition and preferences.
