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Zonalon (Doxepin)

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Top Generic choice

What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Zonalon is an eczema treatment medication available by prescription, used to provide relief from the itchiness, rashes, and dry skin patches associated with this condition. Doxepin, a tricyclic antidepressant drug, blocks histamines from reaching the epidermal skin layer, thereby alleviating these symptoms. This medication may also be prescribed for lichen simplex chronicus of the skin. However, Zonalon is intended for temporary use only and should not be used for more than eight consecutive days. Buy Zonalon from Canada through Canpharm for the lowest cost.

Doxepin, available in capsule form, is a medication primarily used in the treatment of major depressive disorder and anxiety. It belongs to a class of medications called tricyclic antidepressants (TCAs). These work by adjusting the levels of neurotransmitters in the brain, such as serotonin and norepinephrine, to help stabilize mood and reduce anxiety.

Fact Table
Formula C19H21NO
License US FDA, US DailyMed
Bioavailability 13–45%
Legal status Rx-Only
Chemical Name Doxepin
Elimination half-life 8–24 hours
Dosage (Strength) 10mg, 25mg, 50mg, 5% Cream 30g
Pregnancy Consult Doctor
Brands Zonalon
Protein binding 76%
PubChem CID 3158
MedlinePlus a682390
ChEBI 4710
ATC code D04AX01
DrugBank DB01142
KEGG D07875
Routes of administration By mouth and Topical cream available too

Buy Zonalon (Doxepin) online from online Canadian Pharmacy |


Zonalon Cream:

The standard application for Zonalon 5 topical cream is to apply it four times daily as a thin layer, spreading it over the affected area and rubbing it into the skin. Allow three to four hours between applications. Your prescription will specify that Zonalon should be used for a maximum of eight days.

Doxepin Capsules:

Standard dosage for Zonalon tablets is to take one 10mg, 25mg, or 50mg tablet 1x daily as indicated in your prescription. Users should take their tablet 30 minutes before bedtime.


The active ingredient is Doxepin in both Zonalon cream and Capsules.


Zonalon Cream:

For topical use on skin only. Avoid contact with eyes, nose, ears, mouth, or any other body opening. Wash hands thoroughly immediately after use.

Do not exceed the dosage guidelines as indicated in the prescription, and do not use Zonalon for more than eight days.

Inform your doctor of any history of narrow-angle glaucoma or urination problems before starting Zonalon, or if you have used an MAOI inhibitor within the previous 14 days.

Do not cover the skin with any material that directly contacts the skin after application, such as bandages or similar items.

Women who are pregnant or breastfeeding should consult their doctor before using Zonalon.

Store at room temperature and keep out of the reach of children.

Doxepin Capsules:

Doxepin requires caution due to potential allergies, interactions with other medications, and effects on existing medical conditions like heart disease or bipolar disorder. It can impact mental health, especially in younger patients, and should not be mixed with alcohol or CNS depressants. Pregnant or breastfeeding women, the elderly, and those operating machinery need to take special care. Abrupt discontinuation can lead to withdrawal symptoms. Always consult a healthcare provider for personalized guidance.


Zonalon Cream:

Negative drug interactions may occur between Zonalon and other prescription medications, including alprazolam, amitriptyline, baclofen, docusate, cyclobenzaprine, duloxetine, diazepam, dicyclomine, doxycycline, estradiol, fluocinonide, gabapentin, hydroxyzine, levetiracetam, levothyroxine, lisinopril, lovastatin, eszopiclone, pregabalin, melatonin, metronidazole, promethazine, metaxalone, and ondansetron. Inform your doctor of all medications you are currently taking before obtaining a prescription for Zonalon.

Doxepin Capsules:

Doxepin can interact with several drugs, including MAO inhibitors, CNS depressants, anticholinergic drugs, cimetidine, blood thinners, diabetes medications, heart rhythm medications, other antidepressants, thyroid medications, and can be affected by grapefruit juice. It's important to consult a healthcare provider for personalized advice regarding these interactions.

Side Effects

Zonalon Cream:

Possible side effects of Zonalon include drowsiness, dizziness, dry mouth, blurred vision, or taste changes. If side effects occur, consider discontinuing use and consult your doctor to discuss alternative eczema treatment medications.

Doxepin Capsules:

Doxepin can cause side effects like drowsiness, dry mouth, blurred vision, weight gain, and constipation. More serious effects include confusion, irregular heartbeat, skin reactions, seizures, and jaundice. It also carries a risk of increasing suicidal thoughts, particularly in young adults. Immediate medical attention should be sought for severe or concerning symptoms.

Frequently Asked Questions about Zonalon (Doxepin)

What is Zonalon?

Zonalon, containing the active ingredient doxepin, is a tricyclic antidepressant. When applied topically, it helps relieve itching but does not treat symptoms of depression.

What conditions does Zonalon treat?

It is used for treating itching in adults with eczema or other skin conditions that lead to repeated scratching and thickened skin.

How does Zonalon work?

Zonalon works by preventing the effects of histamine, a substance produced by the body that causes itching.

What are the side effects of Zonalon?

Common side effects include burning or stinging where applied, mild drowsiness, and dry mouth. Serious side effects may include severe drowsiness, confusion, severe dry mouth, painful or difficult urination, blurred vision, or new or worsening skin symptoms.

Who should not use Zonalon?

Do not use Zonalon if you are allergic to doxepin, have untreated narrow-angle glaucoma, or have urination problems.

Frequently Asked Questions about Doxepin Capsules

What are Doxepin capsules?

Doxepin capsules are a medication used as part of the miscellaneous anxiolytics, sedatives, and hypnotics drug class, and also as tricyclic antidepressants.

What are the uses of Doxepin capsules?

They are prescribed to treat depression, anxiety, and may be used for other reasons as advised by a doctor.

What should I tell my doctor before taking Doxepin capsules?

Inform your doctor if you have allergies to doxepin or any other medication, trouble passing urine, glaucoma, or if you have taken certain drugs for depression or Parkinson's disease in the last 14 days.

What are important considerations while taking Doxepin capsules?

Avoid alcohol, inform all health care providers about using this medication, and be aware of potential eye problems, increased sunburn risk, and the need for close monitoring if you have diabetes or are over 65 years old. Avoid driving if the medication affects your alertness.

How should Doxepin capsules be taken?

Take Doxepin capsules as prescribed by your doctor, preferably at bedtime if taken once daily. Continue taking them even if you feel well.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.