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Fact Table
| Fact Table | |
|---|---|
| Formula | C4H11N5 |
| License | FDA approved |
| Bioavailability | ~50–60% (oral, immediate-release; slightly reduced in extended-release) |
| Legal status | Prescription Drug |
| Chemical Name | 3-(diaminomethylidene)-1,1-dimethylguanidine |
| Elimination half-life | ~4–8.7 hours |
| Dosage (Strength) | 500mg, 750mg, 1000mg extended-release tablets |
| Pregnancy | Generally safe; consult doctor (Category B) |
| Brands | Glucophage XR, Fortamet, Glumetza |
| Protein binding | Negligible |
| PubChem CID | 4091 |
| MedlinePlus | a696005 |
| ChEBI | 6801 |
| ATC code | A10BA02 |
| DrugBank | DB00331 |
| KEGG | D04966 |
| Routes of administration | By mouth |
Glucophage extended release (XR) is a Type 2 diabetes treatment medication used to lower blood glucose levels and reduce the risk of complications from diabetes like kidney disease, heart disease, or diabetic retinopathy or neuropathy. Metformin is a biguanides class drug that works to decrease the amount of glucose absorbed from food by the body as well as suppressing glucose from the liver and improving insulin sensitivity. You can buy Glucophage XR with a prescription here at Canpharm.
Directions
Standard dosage is to take one Glucophage XR tablet 1x daily, and it is best to take it with food at your evening meal
Ingredients
The active ingredient in Glucophage XR is Metformin
Cautions
Let your doctor know of any history of kidney disease, heart disease, metabolic acidosis, or diabetic ketoacidosis before starting on Glucophage XR
For use with ages 18 and up only
Use of this medication may stimulate ovulation in women and may increase the risk of unintended pregnancy
Users who have any type of surgery or an X-ray or CT scan required dye to be injected in veins may need to refrain from or suspend use of Glucophage until the procedure is completed
Women who are pregnant or breastfeeding should only use this medication if their doctor approves it
Store medication at room temperature and away from moisture, heat, and light
Interactions
Negative drug interactions may occur between Glucophage XR and other Rx or OTC medications, including hydrochlorothiazide, insulin glargine, furosemide, levothyroxine, lisinopril, and simvastatin. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Glucophage XR online.
Side Effects
Glucophage side effects may occur, and some users may experience diarrhea, nausea, vomiting, gas, bloating, fatigue, weakness, stomach pain, headache, constipation, taste changes, or sinus infection. If side effects are seen you may want to discontinue use and meet with a doctor again to discuss blood sugar control medication alternatives and a pharmacist for a lower Glucophage XR price.
Frequently Asked Questions about Glucophage XR (Metformin Extended-Release)
What is Glucophage XR used for?
Glucophage XR (metformin extended-release) is used to manage blood sugar levels in individuals with type 2 diabetes, helping to control high blood sugar.
How does Glucophage XR work?
Glucophage XR works by improving insulin sensitivity, reducing the amount of sugar produced by the liver, and increasing sugar uptake by muscle cells, all of which help lower blood sugar levels.
How should Glucophage XR be taken?
Glucophage XR is typically taken once a day with food to reduce gastrointestinal side effects. The dosage is based on individual blood sugar levels and is adjusted by your doctor.
What are the side effects of Glucophage XR?
Common side effects include gastrointestinal issues like nausea, diarrhea, or upset stomach. Serious side effects can include lactic acidosis (a rare but serious condition) and vitamin B12 deficiency.
How long does it take for Glucophage XR to work?
Glucophage XR begins working to lower blood sugar levels within a few days, but optimal control may take several weeks as your body adjusts to the medication.
Who should not take Glucophage XR?
Glucophage XR should not be taken by individuals with kidney disease, severe liver problems, or a history of lactic acidosis. It should also be avoided by people who are pregnant or breastfeeding unless advised by a doctor.
Can Glucophage XR interact with other medications?
Yes, Glucophage XR can interact with certain medications, including diuretics, corticosteroids, and medications that affect kidney function. Always inform your doctor of all medications you are taking.
Can Glucophage XR cause weight gain?
No, Glucophage XR typically does not cause weight gain and may even help with modest weight loss in some individuals when combined with proper diet and exercise.
How should Glucophage XR be stored?
Store Glucophage XR at room temperature, away from moisture and heat, and keep it out of the reach of children.
Can I stop taking Glucophage XR suddenly?
It is important to follow your doctor’s instructions when discontinuing Glucophage XR. Stopping suddenly may cause a spike in blood sugar levels, which can be dangerous.
