Lumigan (Bimatoprost)

Lumigan RC

Prescription Required
Brand
Dose Size & Price Qty
0.01%
0.03%
0.03% 0.4ml
Generic
Dose Size & Price Qty
0.01%
0.03%
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Fact Table

Fact Table
Formula C25H37NO4
License FDA approved (2001); EMA approved
Bioavailability Minimal systemic absorption (ophthalmic use)
Legal status Prescription only (Rx)
Chemical Name (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic acid monoethanolamide
Elimination half-life ~45 minutes (systemic)
Dosage (Strength) 0.01% and 0.03% ophthalmic solution (one drop once daily in the evening)
Pregnancy Category C – Use only if benefit outweighs risk
Brands Lumigan, Latisse (cosmetic), generics available
Protein binding ~88%
PubChem CID 5280343
MedlinePlus a602019
ChEBI 60842
ATC code S01EE03
DrugBank DB00905
KEGG D01117
Routes of administration Ophthalmic (eye drops)

Lumigan (bimatoprost) is an eye drop used to treat glaucoma and high eye pressure. As a prostaglandin analog, it helps lower pressure inside the eye by improving how fluid drains out. This reduced pressure helps protect the optic nerve and prevent vision loss. Lumigan is used for people with open-angle glaucoma or increased eye pressure. It comes in two strengths, 0.01% and 0.03%, and is meant only for use in the eyes.

Directions

Lumigan is instilled directly into the eye once daily in the evening. The standard dosage is 1 drop in the affected eye or eyes.

Wash your hands before applying the medication and avoid touching the dropper tip to any surface to prevent contamination. If wearing contact lenses, remove them before instilling the drops and wait at least 15 minutes before reinserting them.

When using multiple eye medications, wait at least 5 minutes between each product to allow proper absorption.

Ingredients

The active ingredient in Lumigan is bimatoprost.

Cautions

  • Before using this medication, you may want to consult a healthcare provider about the following:
    • Any existing health conditions
    • Any allergies
    • A list of all medications currently being taken
  • Lumigan can cause gradual darkening of the iris (the colored part of the eye), eyelids, or eyelashes. Iris color changes may be permanent, while eyelid and eyelash changes may reverse after stopping the medication.
  • Changes in eye color often happen slowly over months or years and may not be noticeable at first. Regular eye exams are recommended if visible color changes occur.
  • Lumigan may cause eyelashes in the treated eye to grow longer, thicker, or darker. These eyelash changes usually go away after treatment is stopped.
  • Eye inflammation can occur, and Lumigan should be used with caution if you have active eye inflammation such as uveitis.
  • Swelling in the back of the eye (macular edema) has been reported, especially in people who have had cataract surgery or have other eye risk factors.
  • Eye infections have occurred when the dropper tip becomes contaminated, particularly in people with existing eye surface problems. Avoid touching the bottle tip to your eye or skin.
  • Lumigan contains a preservative that can discolor soft contact lenses. Contact lenses should be removed before use and can be put back in after 15 minutes.

Contraindications

Avoid taking or using this medication if any of the following apply:

  • Hypersensitivity to bimatoprost
  • Allergy to any inactive ingredients

Side Effects

Common side effects of Lumigan include:

  • Eye redness (conjunctival hyperemia)
  • Eye irritation, itching, or pain
  • Blurred vision
  • Eyelid redness or itching
  • Increased eyelash growth or darkening
  • Darkening of the skin around the eyes

These side effects most often affect the treated eye and are usually mild. Eye redness is the most common reaction and is a common reason people notice a change when starting Lumigan.

More serious side effects can include permanent darkening of the iris, eye inflammation, macular edema, or allergic reactions. Post-marketing reports have also included dry eye, light sensitivity, eyelid shape changes, and breathing-related symptoms such as shortness of breath in rare cases. Contact a healthcare provider if you develop persistent eye pain, vision changes, signs of infection, or swelling around the eyes.

Frequently Asked Questions about Lumigan (Bimatoprost)


What is Lumigan used for?

Lumigan (bimatoprost) is primarily used to reduce elevated intraocular pressure (IOP) in people with open-angle glaucoma or ocular hypertension. Lowering IOP helps prevent damage to the optic nerve and potential vision loss.


How does Lumigan work?

Lumigan is a prostaglandin analog that increases the outflow of fluid (aqueous humor) from the eye, thereby reducing intraocular pressure. It mimics natural prostaglandins in the eye to improve drainage through the trabecular meshwork and uveoscleral pathways.


How should Lumigan be applied?

Lumigan is typically applied once daily in the evening as one drop in the affected eye(s). It should be used at the same time each day, and care should be taken to avoid touching the dropper tip to any surface to prevent contamination.


What are the common side effects of Lumigan?

Common side effects include eye redness, itching, eyelash growth, and darkening of the eyelid skin or iris. Some users may also experience dry eyes, blurred vision, or a feeling of a foreign object in the eye.


Can Lumigan cause permanent eye color change?

Yes, Lumigan may cause gradual darkening of the iris, especially in people with mixed-color irises (e.g., green-brown, blue-brown). This change is usually permanent and more noticeable over time with continued use.


Is Lumigan safe to use with contact lenses?

Lumigan contains benzalkonium chloride, which can be absorbed by soft contact lenses. Contact lenses should be removed before applying the drops and can be reinserted at least 15 minutes after use.


What should I do if I miss a dose of Lumigan?

If you miss a dose, skip it and apply the next dose at the regular time. Do not use two doses at once to make up for the missed dose, as this can increase the risk of side effects without providing added benefit.


Can Lumigan be used in both eyes if needed?

Yes, if both eyes have elevated IOP or glaucoma, Lumigan can be prescribed for use in both eyes. However, only use it as directed by a healthcare provider, and never apply more drops than recommended.


Are there any medications that interact with Lumigan?

There are no major drug interactions commonly associated with Lumigan, but using multiple eye medications can affect absorption or increase side effects. Always inform your healthcare provider of all medications you use, including over-the-counter products.


Is Lumigan the same as Latisse?

Lumigan and Latisse both contain bimatoprost, but they are approved for different uses. Lumigan treats elevated eye pressure, while Latisse is used to enhance eyelash growth. They have different formulations and should not be substituted for each other without a doctor’s guidance.

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