| Fact Table | |
|---|---|
| Formula | C25H37NO4 |
| License | FDA approved (2001); EMA approved |
| Bioavailability | Minimal systemic absorption (ophthalmic use) |
| Legal status | Prescription only (Rx) |
| Chemical Name | (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic acid monoethanolamide |
| Elimination half-life | ~45 minutes (systemic) |
| Dosage (Strength) | 0.01% and 0.03% ophthalmic solution (one drop once daily in the evening) |
| Pregnancy | Category C – Use only if benefit outweighs risk |
| Brands | Lumigan, Latisse (cosmetic), generics available |
| Protein binding | ~88% |
| PubChem CID | 5280343 |
| MedlinePlus | a602019 |
| ChEBI | 60842 |
| ATC code | S01EE03 |
| DrugBank | DB00905 |
| KEGG | D01117 |
| Routes of administration | Ophthalmic (eye drops) |
Lumigan (bimatoprost) is an eye drop used to treat glaucoma and high eye pressure. As a prostaglandin analog, it helps lower pressure inside the eye by improving how fluid drains out. This reduced pressure helps protect the optic nerve and prevent vision loss. Lumigan is used for people with open-angle glaucoma or increased eye pressure. It comes in two strengths, 0.01% and 0.03%, and is meant only for use in the eyes.
Lumigan is instilled directly into the eye once daily in the evening. The standard dosage is 1 drop in the affected eye or eyes.
Wash your hands before applying the medication and avoid touching the dropper tip to any surface to prevent contamination. If wearing contact lenses, remove them before instilling the drops and wait at least 15 minutes before reinserting them.
When using multiple eye medications, wait at least 5 minutes between each product to allow proper absorption.
The active ingredient in Lumigan is bimatoprost.
Avoid taking or using this medication if any of the following apply:
Common side effects of Lumigan include:
These side effects most often affect the treated eye and are usually mild. Eye redness is the most common reaction and is a common reason people notice a change when starting Lumigan.
More serious side effects can include permanent darkening of the iris, eye inflammation, macular edema, or allergic reactions. Post-marketing reports have also included dry eye, light sensitivity, eyelid shape changes, and breathing-related symptoms such as shortness of breath in rare cases. Contact a healthcare provider if you develop persistent eye pain, vision changes, signs of infection, or swelling around the eyes.
What is Lumigan used for?
Lumigan (bimatoprost) is primarily used to reduce elevated intraocular pressure (IOP) in people with open-angle glaucoma or ocular hypertension. Lowering IOP helps prevent damage to the optic nerve and potential vision loss.
How does Lumigan work?
Lumigan is a prostaglandin analog that increases the outflow of fluid (aqueous humor) from the eye, thereby reducing intraocular pressure. It mimics natural prostaglandins in the eye to improve drainage through the trabecular meshwork and uveoscleral pathways.
How should Lumigan be applied?
Lumigan is typically applied once daily in the evening as one drop in the affected eye(s). It should be used at the same time each day, and care should be taken to avoid touching the dropper tip to any surface to prevent contamination.
What are the common side effects of Lumigan?
Common side effects include eye redness, itching, eyelash growth, and darkening of the eyelid skin or iris. Some users may also experience dry eyes, blurred vision, or a feeling of a foreign object in the eye.
Can Lumigan cause permanent eye color change?
Yes, Lumigan may cause gradual darkening of the iris, especially in people with mixed-color irises (e.g., green-brown, blue-brown). This change is usually permanent and more noticeable over time with continued use.
Is Lumigan safe to use with contact lenses?
Lumigan contains benzalkonium chloride, which can be absorbed by soft contact lenses. Contact lenses should be removed before applying the drops and can be reinserted at least 15 minutes after use.
What should I do if I miss a dose of Lumigan?
If you miss a dose, skip it and apply the next dose at the regular time. Do not use two doses at once to make up for the missed dose, as this can increase the risk of side effects without providing added benefit.
Can Lumigan be used in both eyes if needed?
Yes, if both eyes have elevated IOP or glaucoma, Lumigan can be prescribed for use in both eyes. However, only use it as directed by a healthcare provider, and never apply more drops than recommended.
Are there any medications that interact with Lumigan?
There are no major drug interactions commonly associated with Lumigan, but using multiple eye medications can affect absorption or increase side effects. Always inform your healthcare provider of all medications you use, including over-the-counter products.
Is Lumigan the same as Latisse?
Lumigan and Latisse both contain bimatoprost, but they are approved for different uses. Lumigan treats elevated eye pressure, while Latisse is used to enhance eyelash growth. They have different formulations and should not be substituted for each other without a doctor’s guidance.
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (e.g., different shape or color), as trademark laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.